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BMT-124110 Formate
🥰Excellent
Catalog No. T10572L
Alias BMT-124110 Formate(1679371-59-5 Free base)
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM.
BMT-124110 Formate
🥰Excellent
Purity: 99.52%
Catalog No. T10572LAlias BMT-124110 Formate(1679371-59-5 Free base)
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $430 | In Stock | In Stock | |
| 10 mg | $636 | In Stock | In Stock | |
| 25 mg | $987 | In Stock | In Stock | |
| 50 mg | $1,360 | In Stock | In Stock | |
| 100 mg | $1,830 | In Stock | In Stock | |
| 500 mg | $3,680 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $449 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Batch Information
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Purity:99.52%
ee:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM. |
| Targets&IC50 | AAK1:0.9 nM, GAK:99 nM, AAK1 (cells):3.2±1.4, BIKE:17 nM |
| In vitro | BMT-124110 exhibits a cellular IC50 of 3.2±1.4 nM against AAK1.[1] |
| In vivo | BMT-124110 (30 mM; pH 4; 110–30 nA; 3 minutes; naive male rats) is added directly onto the spinal covered by micro iontophoresis, leading to a reduction in windup-induced activity in 10/14 animals.[1] |
| Synonyms | BMT-124110 Formate(1679371-59-5 Free base) |
| Molecular Weight | 344.41 |
| Formula | C22H20N2O2 |
| Smiles | O=C(C1=CC=CC=C1)NC2=CC=CC(C(NC3=C(CC)C=CC=C3)=O)=C2.[H]C(O)=O |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.15 mg/mL (12.05 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
threoninkinasethreonin kinaseTGF-β/SmadTGFβTGFbeta/SmadTGF-betaTGFbetaTGF-b/SmadTGFbSmadSerinekinaseSerine kinaseGAKbone morphogenetic protein (BMP)BMT-124110 FormateBMT124110 FormateBMT 124110 FormateBIKEAP2associatedkinase1AP2 associated kinase 1AAK1(AP2associatedkinase1)AAK1 (AP2 associated kinase 1)AAK11679371-59-5 Free base1679371-59-5
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