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Duocarmycin DM free base (Synonyms: Duocarmycin)

Name: Duocarmycin DM free base
Brand: TargetMol
SKU: T11119
Price: 496 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T11119 Copy Product Info

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Duocarmycin DM free base is a potent DNA alkylator and antitumor antibiotic. It induces DNA damage via sequence-specific alkylation in the minor groove, commonly used as an ADC payload in cancer research.

Duocarmycin DM free base

Copy Product Info

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Catalog No. T11119

Synonyms Duocarmycin

Cas No. 1116745-06-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$288	-	In Stock
5 mg	$496	-	In Stock
10 mg	Preferential	-	In Stock
25 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Duocarmycin DM free base is a potent DNA alkylator and antitumor antibiotic. It induces DNA damage via sequence-specific alkylation in the minor groove, commonly used as an ADC payload in cancer research.
In vitro	Duocarmycin DM free base exhibits picomolar cytotoxicity (IC50 = 3.87-22 pM) by alkylating adenine N3 in the DNA minor groove [1][2].
Synonyms	Duocarmycin

Chemical Properties

Molecular Weight	463.96
Formula	C₂₆H₂₆ClN₃O₃
Cas No.	1116745-06-2
Smiles	C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(OCCN(C)C)C4)C1)C=C(O)C=5C2=CC=CC5
Relative Density.	1.345 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (86.21 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1554 mL	10.7768 mL	21.5536 mL	107.7679 mL
5 mM	0.4311 mL	2.1554 mL	4.3107 mL	21.5536 mL
10 mM	0.2155 mL	1.0777 mL	2.1554 mL	10.7768 mL
20 mM	0.1078 mL	0.5388 mL	1.0777 mL	5.3884 mL
50 mM	0.0431 mL	0.2155 mL	0.4311 mL	2.1554 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc