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BMS-929075

Name: BMS-929075
Brand: TargetMol
SKU: T26863
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26863Cas No. 1217338-97-0

Alias BMS929075, BMS 929075

BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.

BMS-929075

😃Good

Purity: 99.94%

Catalog No. T26863Alias BMS929075, BMS 929075Cas No. 1217338-97-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$190	In Stock	In Stock
5 mg	$480	In Stock	In Stock
10 mg	$687	In Stock	In Stock
25 mg	$1,080	In Stock	In Stock
50 mg	$1,480	In Stock	In Stock
100 mg	$1,990	-	In Stock
500 mg	$3,920	-	In Stock
1 mL x 10 mM (in DMSO)	$598	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA FNMR HNMR HPLC

Product Introduction

Bioactivity

Description	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.
Targets&IC50	HepG2 cells:>12.5 µM(CC50), Huh7 cells:60 µM(CC50)
In vitro	BMS-929075 (0-60 µM) exhibited cytotoxicity with CC50 values of 60 µM, >12.5 µM, and >50 µM in Huh-7 cells, HepG2 cells, and primary human hepatocytes, respectively. [1]
In vivo	BMS-929075 (i.v. 2 mg/kg; orally 6 mg/kg) showed good pharmacokinetic parameters with an oral bioavailability of 48% in rats.[1]
Synonyms	BMS929075, BMS 929075

Chemical Properties

Molecular Weight	538.54
Formula	C₃₁H₂₄F₂N₄O₃
Cas No.	1217338-97-0
Smiles	N(C(=O)C1=CC(=C(C)C=C1)C=2C(F)=C3C(C(NC)=O)=C(OC3=CC2)C4=CC=C(F)C=C4)C5(CC5)C=6N=CC=CN6
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (51.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8569 mL	9.2844 mL	18.5687 mL	92.8436 mL
5 mM	0.3714 mL	1.8569 mL	3.7137 mL	18.5687 mL
10 mM	0.1857 mL	0.9284 mL	1.8569 mL	9.2844 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6422 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc