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6α-Prostaglandin I1 (Synonyms: 6α-Prostaglandin I1)

Name: 6α-Prostaglandin I1
Brand: TargetMol
SKU: T36238
Rating: 4.5 (1 reviews)

Catalog No. T36238 Copy Product Info

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6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. It promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration-dependent manner but is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting this response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, nearly 900-fold higher than that of PGI2 (0.4 ng/ml).

6α-Prostaglandin I1

Copy Product Info

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Catalog No. T36238

Synonyms 6α-Prostaglandin I1

Cas No. 62777-90-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$232	35 days	35 days
5 mg	$993	35 days	35 days
10 mg	$1,790	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Synonyms

6α-Prostaglandin I1

Chemical Properties

Molecular Weight	354.487
Formula	C₂₀H₃₄O₅
Cas No.	62777-90-6
Smiles	[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C[C@@H](CCCCC(O)=O)O2

Storage & Solubility Information

Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: >5 (from 6b-PGI1), Sonication is recommended. Ethanol: >20 mg/mL (from 6b-PGI1), Sonication is recommended. DMF: >10 (from 6b-PGI1), Sonication is recommended. PBS (pH 7.2): >80 μg (from 6b-PGI1), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc