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6α-Prostaglandin I1

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Catalog No. T36238Cas No. 62777-90-6
Alias 6α-Prostaglandin I1

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. It promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration-dependent manner but is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting this response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, nearly 900-fold higher than that of PGI2 (0.4 ng/ml).

6α-Prostaglandin I1
Other Forms of 6α-Prostaglandin I1:
6β-Prostaglandin I1T3623962770-50-7
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6α-Prostaglandin I1

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Catalog No. T36238Alias 6α-Prostaglandin I1Cas No. 62777-90-6
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. It promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration-dependent manner but is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting this response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, nearly 900-fold higher than that of PGI2 (0.4 ng/ml).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$23235 days35 days
5 mg$99335 days35 days
10 mg$1,79035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. It promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration-dependent manner but is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting this response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, nearly 900-fold higher than that of PGI2 (0.4 ng/ml).
Synonyms6α-Prostaglandin I1
Chemical Properties
Molecular Weight354.487
FormulaC20H34O5
Cas No.62777-90-6
Smiles[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)CCCCC)[C@@]1([H])C[C@@H](CCCCC(O)=O)O2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: >5 (from 6b-PGI1), Sonication is recommended.
Ethanol: >20 mg/mL (from 6b-PGI1), Sonication is recommended.
DMF: >10 (from 6b-PGI1), Sonication is recommended.
PBS (pH 7.2): >80 μg (from 6b-PGI1), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

6α-Prostaglandin I-16αProstaglandin I16α Prostaglandin I16a-Prostaglandin I16alpha-Prostaglandin I1
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