keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATV041, an orally active compound that combines features of Ibuprofen and nucleotide analogues, enhances the oral pharmacokinetic (PK) profile and tissue distribution, exhibiting anti-mouse hepatitis virus (MHV) activity. The compound demonstrates a dose-dependent reduction in viral load, tissue damage, and virus-induced inflammation [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | ATV041, an orally active compound that combines features of Ibuprofen and nucleotide analogues, enhances the oral pharmacokinetic (PK) profile and tissue distribution, exhibiting anti-mouse hepatitis virus (MHV) activity. The compound demonstrates a dose-dependent reduction in viral load, tissue damage, and virus-induced inflammation [1]. |
In vitro | The chemical compound ATV041 exhibits inhibitory activity against CCoV, FIPV, and TGEV with EC50 values of 1.406 µM, 7.34 µM, and 3.777 µM, respectively [1]. |
In vivo | ATV041 (200 mg/kg; oral; single dose) distributes extensively and rapidly throughout the plasma, liver, lungs, and kidney tissues [1]. When administered orally in single doses of 10, 50, and 200 mg/kg, ATV041 inhibits viral replication in the liver and lungs in a dose-dependent manner. Additionally, ATV041 decreases the expression of inflammatory cytokines TNF-α, IL-1β, IL-6, IFN-γ, and CXCL10, leading to amelioration of tissue damage [1]. |
Molecular Weight | 479.53 |
Formula | C25H29N5O5 |
CAS No. | 2935937-67-8 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ATV041 2935937-67-8 inhibitor inhibit