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p-Aminobenzamidine dihydrochloride
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Catalog No. T60248Cas No. 2498-50-2
Alias p-Aminobenzamidine dihydrochloride
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2].
p-Aminobenzamidine dihydrochloride
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Purity: 99.56%
Catalog No. T60248Alias p-Aminobenzamidine dihydrochlorideCas No. 2498-50-2
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 g | $32 | - | In Stock | |
| 5 g | $68 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.56%
Appearance:Solid
Color:White to Yellow
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Product Introduction
p-Aminobenzamidine dihydrochloride AI Summary
p-Aminobenzamidine dihydrochloride has demonstrated significant bioactivity in various assays. It shows antiplasmodial activity against Plasmodium falciparum W2 after 72 hours with an IC50 value of 12589.25 nM as determined by the SYBR green assay. Additionally, it has a potency of 14125.4 nM in inhibiting the proliferation of Plasmodium falciparum W2, 316.2 nM against Plasmodium falciparum GB4, 17782.8 nM in inhibiting the Human Apurinic/apyrimidinic Endonuclease 1 (APE1), and 25.1 nM in inhibiting Histone Lysine Methyltransferase G9a. The compound also shows binding affinity and inhibitory activity against human alpha thrombin with a Ki value of 95000.0 nM, recombinant trypsin 1 with a Ki value of 8900.0 nM, and recombinant trypsin 4 with a Ki value of 13100.0 nM. These findings indicate that p-Aminobenzamidine dihydrochloride possesses potential in affecting the proliferation of Plasmodium falciparum and targeting enzymes related to nucleic acid repair, histone modification, and proteolytic activity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2]. |
| Synonyms | p-Aminobenzamidine dihydrochloride |
| Molecular Weight | 208.088 |
| Formula | C7H11Cl2N3 |
| Cas No. | 2498-50-2 |
| Smiles | Cl.Cl.NC(=N)C1=CC=C(N)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (240.28 mM), Sonication and heating to 80℃ are recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.81 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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