TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 60.00 | |
50 μg | 5 days | $ 184.00 | |
500 μg | 5 days | $ 1,490.00 | |
1 mg | 5 days | $ 2,230.00 |
Description | TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B. |
Species | Cynomolgus |
Expression System | Human Cells |
Tag | C-6His |
Accession Number | A0A2K5TXK0 |
Synonyms | Death Receptor 5, TRAILR2, CD262, DR5, TNFRSF10B, TRAIL-R2, ZTNFR9, Tumor Necrosis Factor Receptor Superfamily Member 10B, TRICK2, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TRAIL Receptor 2 |
Amino Acid | Ile58-Ser212 |
Construction | Recombinant Cynomolgus TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile58-Ser212 is expressed with a 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 22-30 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | TNFRSF10B is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B. TNFRSF10B is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”. TNFRSF10B expression is regulated by the tumor suppressor p53. It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B. |
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Please read the User Guide of Recombinant Proteins for more specific information.
TRAIL R2/DR5/TNFRSF10B Protein, Cynomolgus, Recombinant (His) DR-5 TRICK-2 Death Receptor 5 TRAILR2 CD262 DR5 TRAILR-2 CD 262 TNFRSF10B CD-262 TRAIL-R2 ZTNFR9 Tumor Necrosis Factor Receptor Superfamily Member 10B TRICK 2 ZTNFR-9 TRICK2 DR 5 ZTNFR 9 TRAILR 2 KILLER TNF-Related Apoptosis-Inducing Ligand Receptor 2 TRAIL Receptor 2 recombinant recombinant-proteins proteins protein