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(S)-AMPA HCl

Name: (S)-AMPA HCl
Brand: TargetMol
SKU: T21271L
Price: 256 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21271L

Alias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)

(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.

(S)-AMPA HCl

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Purity: 99.18%

Catalog No. T21271LAlias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)

(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$256	-	In Stock
5 mg	$564	-	In Stock
10 mg	$847	-	In Stock
25 mg	$1,426	-	In Stock
50 mg	$2,139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.18%

ee:100%

Appearance:Solid

Color:White

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COA CSFC HNMR IC LCMS ORP

Product Introduction

Bioactivity

Description	(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.
Targets&IC50	AMPA:3.1 μM (EC50)
In vitro	(S)-AMPA HCl is a potent and selective AMPA receptor agonist. (S)-AMPA HCl (1 μM) infusion significantly reduced CGRP release in a CB-dependent manner. [1] In cultured mouse cortical neurons, (S)-AMPA HCl induces apoptotic states such as cell contraction, neurite vesicles and nuclear enrichment, with an EC50 of 3.1 μM.[2]
In vivo	Single focal injection of the (S)-AMPA HCl（6 nmol/microliters) into rat dorsal hippocampus resulted in widespread neurodegeneration with 90-100% loss of hippocampal pyramidal cells in CA1, CA2, CA3 and CA4 subfields, and 50-70% loss of dentate granule (DG) cells.[3]
Synonyms	L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)

Chemical Properties

Molecular Weight	222.63
Formula	C₇H₁₁ClN₂O₄
Smiles	Cl.Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (112.29 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.4918 mL	22.4588 mL	44.9176 mL	224.5879 mL
5 mM	0.8984 mL	4.4918 mL	8.9835 mL	44.9176 mL
10 mM	0.4492 mL	2.2459 mL	4.4918 mL	22.4588 mL
20 mM	0.2246 mL	1.1229 mL	2.2459 mL	11.2294 mL
50 mM	0.0898 mL	0.4492 mL	0.8984 mL	4.4918 mL
100 mM	0.0449 mL	0.2246 mL	0.4492 mL	2.2459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc