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(S)-AMPA HCl

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Catalog No. T21271L
Alias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)

(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.

(S)-AMPA HCl
Other Forms of (S)-AMPA HCl:

(S)-AMPA HCl

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Purity: 99.18%
Catalog No. T21271LAlias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.
Pack SizePriceAvailabilityQuantity
1 mg$256In Stock
5 mg$564In Stock
10 mg$847In Stock
25 mg$1,426In Stock
50 mg$2,139In Stock
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Purity:99.18%
ee:100%
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Product Introduction

Bioactivity
Description
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.
Targets&IC50
AMPA:3.1 μM (EC50)
In vitro
(S)-AMPA HCl is a potent and selective AMPA receptor agonist. (S)-AMPA HCl (1 μM) infusion significantly reduced CGRP release in a CB-dependent manner. [1]
In cultured mouse cortical neurons, (S)-AMPA HCl induces apoptotic states such as cell contraction, neurite vesicles and nuclear enrichment, with an EC50 of 3.1 μM.[2]
In vivo
Single focal injection of the (S)-AMPA HCl（6 nmol/microliters) into rat dorsal hippocampus resulted in widespread neurodegeneration with 90-100% loss of hippocampal pyramidal cells in CA1, CA2, CA3 and CA4 subfields, and 50-70% loss of dentate granule (DG) cells.[3]
SynonymsL-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)
Chemical Properties
Molecular Weight222.63
FormulaC7H11ClN2O4
SmilesCl.Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

(S)AMPAHCl（83643883Freebase）
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