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Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)
(Synonyms: pleiotrophin, Osf-1, Osf1, OSF, HBNF, HBGF-8, HB-GAM, HBBN, HARP) Copy Product InfoSynonyms: pleiotrophin, Osf-1, Osf1, OSF, HBNF, HBGF-8, HB-GAM, HBBN, HARP
Catalog No. TMPY-02850 Copy Product Info
Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P63089.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $47 | 7-10 days | 7-10 days | |
| 10 µg | $73 | 7-10 days | 7-10 days | |
| 20 µg | $118 | 7-10 days | 7-10 days | |
| 50 µg | $230 | 7-10 days | 7-10 days | |
| 100 µg | $443 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P63089. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | P63089 |
| Construction | A DNA sequence encoding the mouse PTN (P63089) (Gly 33-Asp 168) was fused with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu |
| Protein Purity | > 85 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | pleiotrophin, Osf-1, Osf1, OSF, HBNF, HBGF-8, HB-GAM, HBBN, HARP |
| Research Background | HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damage in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. |
| Molecular Weight | 43.7 kDa (predicted); 47 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) chemical structure | Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc) molecular weight
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