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Antalarmin

Name: Antalarmin
Brand: TargetMol
SKU: T70433
Rating: 4.5 (1 reviews)

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Catalog No. T70433Cas No. 157284-96-3

Antalarmin is a selective and potent corticotropin-releasing factor receptor 1 (CRHR1) antagonist that crosses the blood-brain barrier and blocks CRF activation and carrageenan-induced subcutaneous inflammation in rats.

Antalarmin

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Catalog No. T70433Cas No. 157284-96-3

Pack Size	Price	Availability
25 mg	$454	1-2 weeks
50 mg	$614	1-2 weeks
100 mg	$828	1-2 weeks

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Product Introduction

Bioactivity

Description	Antalarmin is a selective and potent corticotropin-releasing factor receptor 1 (CRHR1) antagonist that crosses the blood-brain barrier and blocks CRF activation and carrageenan-induced subcutaneous inflammation in rats.
Targets&IC50	CRHR1:2.7 nM (Ki)
In vitro	Antalarmin (100 nM; 48 hours) treatment was able to block CRF-induced increases in PKAIIβ levels in hippocampal neurons derived from Tg2576 mice[2].
In vivo	In the chronic mild stress model using BALB/cByJIco male mice, intraperitoneal administration of Antalarmin (10 mg/kg; once daily for 4 weeks) was able to significantly improve the physical state of the mice[1].

Chemical Properties

Molecular Weight	378.55
Formula	C₂₄H₃₄N₄
Cas No.	157284-96-3
Smiles	N=1C(=NC(=C2C1N(C=3C(=CC(=CC3C)C)C)C(=C2C)C)N(CC)CCCC)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (52.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6417 mL	13.2083 mL	26.4166 mL	132.0829 mL
5 mM	0.5283 mL	2.6417 mL	5.2833 mL	26.4166 mL
10 mM	0.2642 mL	1.3208 mL	2.6417 mL	13.2083 mL
20 mM	0.1321 mL	0.6604 mL	1.3208 mL	6.6041 mL
50 mM	0.0528 mL	0.2642 mL	0.5283 mL	2.6417 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc