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Anti-LYVE1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01093
Anti-LYVE1 Polyclonal Antibody is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Polyclonal Antibody can be used in WB,ELISA.
Anti-LYVE1 Polyclonal Antibody
Anti-LYVE1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01093
Anti-LYVE1 Polyclonal Antibody is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Polyclonal Antibody can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $373 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-LYVE1 Polyclonal Antibody is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Polyclonal Antibody can be used in WB,ELISA. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Blood cell lysates Lane 3: Mouse LympHnode tissue lysates Lane 4: Mouse Large intestine tissue lysates Lane 5: Rat Thyroid gland tissue lysates Lane 6: Rat Spleen tissue lysates Lane 7: Rat LympHnode tissue lysates Lane 8: Rat Large intestine tissue lysates Lane 9: Human Huvec cell lysates Lane 10: Human K562 cell lysates Primary: Anti-LYVE-1 (TMAB-01093) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kDa Observed band size: 58 kDa |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Research Background | The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. |
| Immunogen | KLH conjugated synthetic peptide: human LYVE-1 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Endothelial Cell Markers,Endothelium |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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