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Imazalil

Name: Imazalil
Brand: TargetMol
SKU: T1113
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1113Cas No. 35554-44-0

Alias Enilconazole, chloramizole

Enilconazole is an Agricultural fungicide Enilconazole is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. It is also called Imazalil (Enilconazole), Chloramizole, Freshgard, Fungaflor, and Nuzone

Imazalil

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Purity: 99.23%

Catalog No. T1113Alias Enilconazole, chloramizoleCas No. 35554-44-0

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$59	In Stock	In Stock
1 g	$85	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Imazalil AI Summary

Imazalil exhibits a broad spectrum of bioactivities and therapeutic potential. It shows significant antifungal activity against various fungi, including Aspergillus fumigatus, Drechslera sorokiniana, and Fusarium culmorum, with MIC values ranging from 0.1 to 5.0 μg/mL. Additionally, it is effective against Colletotrichum capsici, with an ED50 of less than 5.0 μgAi/mL. The compound demonstrates antiviral properties, including moderate inhibition of SARS-CoV-2 in Vero E6 cells and HRCE cells, and has an IC50 value greater than 20,000 nM for SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Imazalil exhibits diverse bioactivities, including inhibition of mitochondrial division, rescue of yeast growth from Plasmodium Falciparum HSP40-mediated toxicity, and antagonism of thyroid hormone receptor beta signaling. It inhibits the delayed death of malarial parasite plastid, antagonizes farnesoid X receptor signaling, and shows activity as an agonist for peroxisome proliferator-activated receptor gamma signaling and vitamin D receptor signaling. The compound also acts as an inverse agonist for GLP-1 receptor and activates both rat and human pregnane X receptor signaling pathways. It inhibits survival of Plasmodium falciparum in red blood cells, human tyrosyl-DNA phosphodiesterase 1, TDP-43, and alpha-syn. Moreover, Imazalil inhibits IDO1 enzyme activity with an IC50 value of 23,000 nM and demonstrates cytotoxicity against mouse P815B cells with an LD50 value greater than 25.0 μM. In the enzymatic assay, it shows -0.06% inhibition of human HDAC6 enzyme using a commercial peptide substrate and -8.66% inhibition using a custom peptide substrate. While the compound exhibited beta-blocking activity in stepwise linear discriminate analysis, it was inactive in this specific assay with an activity value of -3.17. Overall, the diverse bioactivities of Imazalil suggest its potential therapeutic applications in treating fungal infections, malaria, viral infections, and metabolic disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Enilconazole is an Agricultural fungicide Enilconazole is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. It is also called Imazalil (Enilconazole), Chloramizole, Freshgard, Fungaflor, and Nuzone
Synonyms	Enilconazole, chloramizole

Chemical Properties

Molecular Weight	297.18
Formula	C₁₄H₁₄Cl₂N₂O
Cas No.	35554-44-0
Smiles	C(CN1C=CN=C1)(OCC=C)C2=C(Cl)C=C(Cl)C=C2
Relative Density.	1.348

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (84.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3650 mL	16.8248 mL	33.6496 mL	168.2482 mL
5 mM	0.6730 mL	3.3650 mL	6.7299 mL	33.6496 mL
10 mM	0.3365 mL	1.6825 mL	3.3650 mL	16.8248 mL
20 mM	0.1682 mL	0.8412 mL	1.6825 mL	8.4124 mL
50 mM	0.0673 mL	0.3365 mL	0.6730 mL	3.3650 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc