Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMX-4116, a casein kinase 1α (CK1α) degrader, preferentially degrades CK1α in MOLT4, Jurkat, and MM.1S cells, exhibiting degradation concentration 50s (DC50s) below 200 nM. TMX-4116 is utilized in the research of multiple myeloma [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,650.00 | |
50 mg | 10-14 weeks | $ 2,150.00 | |
100 mg | 10-14 weeks | $ 3,310.00 |
Description | TMX-4116, a casein kinase 1α (CK1α) degrader, preferentially degrades CK1α in MOLT4, Jurkat, and MM.1S cells, exhibiting degradation concentration 50s (DC50s) below 200 nM. TMX-4116 is utilized in the research of multiple myeloma [1]. |
In vitro | TMX-4116, at a concentration of 1 μM for 4 hours, demonstrates a significant preference for degrading CK1α in MOLT4 cells, as confirmed by Western Blot Analysis. At a lower concentration of 250 nM, TMX-4116 specifically induces the degradation of CK1α without affecting the levels of PDE6D, IKZF1, and IKZF3 in the same cell line. Further analysis revealed that TMX-4116 exhibits a strong selective degradation of CK1α across different cell lines, including MOLT4, Jurkat, and MM.1S, with a DC50 value of less than 200 nM, highlighting its efficacy over a range of concentrations. |
Molecular Weight | 389.43 |
Formula | C17H19N5O4S |
CAS No. | 2766385-56-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TMX-4116 2766385-56-0 inhibitor inhibit