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Loxeen

Name: Loxeen
Brand: TargetMol
SKU: T1072
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1072Cas No. 6856-31-1

Alias Pridinol methanesulfonate

Loxeen (Pridinol methanesulfonate) is used as an anticholinergic and as an antiparkinsonian agent.

Loxeen

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Purity: 99.46%

Catalog No. T1072Alias Pridinol methanesulfonateCas No. 6856-31-1

Loxeen (Pridinol methanesulfonate) is used as an anticholinergic and as an antiparkinsonian agent.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	In Stock	-
50 mg	$35	In Stock	-
100 mg	$48	In Stock	-
500 mg	$116	Inquiry	Inquiry
1 g	$168	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.46%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Loxeen AI Summary

Loxeen exhibits a broad spectrum of bioactivities, making it a versatile candidate for pharmacological research. It inhibits multiple cellular pathways and enzyme activities, including membrane-permeable IMPase potentiated by lithium, the ERK signaling pathway when stimulated with EGF, and Chronic Active B-Cell Receptor Signaling. Additionally, it acts as an inhibitor of Cytochrome P450 2D6, Histone Lysine Methyltransferase G9a, HP1-beta Chromodomain interactions with Methylated Histone Tails, Polymerase Iota, USP1/UAF1, ERG Ets/DNA interaction, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). Loxeen shows notable antiviral activities, particularly against SARS-CoV-2, mitigating induced cytotoxicity in Vero E6 and Caco-2 cells and inhibiting the SARS-CoV-2 3CL-Pro protease by 15.42% at 20 µM. It also inhibits viral activities against the Marburg Virus and Lassa Virus by preventing their binding or entry into cells. Moreover, it has demonstrated efficacy in inhibiting the malarial parasite plastid. In transporter assays, Loxeen significantly inhibited sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, achieving inhibitions of 95.39% and 95.92%, respectively, at 10 µM. While its inhibition of SARS-CoV-2 in VERO-6 cells was less pronounced, it still demonstrated multifaceted bioactivities that warrant further investigation for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Loxeen (Pridinol methanesulfonate) is used as an anticholinergic and as an antiparkinsonian agent.
Synonyms	Pridinol methanesulfonate

Chemical Properties

Molecular Weight	391.52
Formula	C₂₀H₂₅NO·CH₄O₃S
Cas No.	6856-31-1
Smiles	CS(=O)(=O)O.OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (127.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5541 mL	12.7707 mL	25.5415 mL	127.7074 mL
5 mM	0.5108 mL	2.5541 mL	5.1083 mL	25.5415 mL
10 mM	0.2554 mL	1.2771 mL	2.5541 mL	12.7707 mL
20 mM	0.1277 mL	0.6385 mL	1.2771 mL	6.3854 mL
50 mM	0.0511 mL	0.2554 mL	0.5108 mL	2.5541 mL
100 mM	0.0255 mL	0.1277 mL	0.2554 mL	1.2771 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc