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Metergoline

🥰Excellent
Catalog No. T4008Cas No. 17692-51-2
Alias Methergoline, Liserdol

Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.

Metergoline

Metergoline

🥰Excellent
Purity: 99.97%
Catalog No. T4008Alias Methergoline, LiserdolCas No. 17692-51-2
Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$29In StockIn Stock
25 mgPreferentialIn StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.97%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
Targets&IC50
5-HT2C receptor:8.75 (pKi), 5-HT2A receptor:8.64 (pKi), 5-HT2B receptor:8.75 (pKi), 5-HT7 receptor (human):16 nM (Ki)
SynonymsMethergoline, Liserdol
Chemical Properties
Molecular Weight403.52
FormulaC25H29N3O2
Cas No.17692-51-2
SmilesCN1C2=C3C([C@@]4([C@@](CC3=C1)(N(C)C[C@H](CNC(OCC5=CC=CC=C5)=O)C4)[H])[H])=CC=C2
Relative Density.1.25 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40.4 mg/mL (100.12 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.96 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4782 mL12.3910 mL24.7819 mL123.9096 mL
5 mM0.4956 mL2.4782 mL4.9564 mL24.7819 mL
10 mM0.2478 mL1.2391 mL2.4782 mL12.3910 mL
20 mM0.1239 mL0.6195 mL1.2391 mL6.1955 mL
50 mM0.0496 mL0.2478 mL0.4956 mL2.4782 mL
100 mM0.0248 mL0.1239 mL0.2478 mL1.2391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SodiumChannelSodium ChannelSerotonin ReceptorregulationpsychoactiveprolactinpremenstrualNa+ channelsNa channelsMetergolineInhibitorinhibithormonedysphoricDopamineReceptorDopamine ReceptorDopaminedisorderaffective5-hydroxytryptamine Receptor5HTReceptor5-HT75-HT25-HT15-HT Receptor5HT Receptor
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