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TM6089

Name: TM6089
Brand: TargetMol
SKU: T17105
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17105Cas No. 863421-32-3

TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.

TM6089

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Purity: 99.70%

Catalog No. T17105Cas No. 863421-32-3

TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$117	-	In Stock
10 mg	$176	-	In Stock
25 mg	$317	-	In Stock
50 mg	$475	-	In Stock
100 mg	$693	-	In Stock
200 mg	$931	-	In Stock
1 mL x 10 mM (in DMSO)	$125	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.70%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

TM6089 AI Summary

TM6089 exhibits a variety of bioactivities. It modulates miRNAs, including the activation and inhibition of miR-21, and inhibits several key enzymes and proteins such as AmpC Beta-Lactamase, Nrf2, ELG1-dependent DNA repair, Human Flap endonuclease 1 (FEN1), and PTHR. Additionally, it re-activates p53, induces genotoxicity in HEK293T cells, delays death inhibition of the malarial parasite plastid, modulates firefly luciferase inhibitor/activator, and alters PINK1 expression. Moreover, TM6089 has been screened for potential antiviral activity against the Foot and Mouth Disease Virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.

Chemical Properties

Molecular Weight	306.34
Formula	C₁₃H₁₄N₄O₃S
Cas No.	863421-32-3
Smiles	Cn1c(N)c(C(=O)CSc2ccccn2)c(=O)n(C)c1=O
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.5 mg/mL (122.41 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2643 mL	16.3217 mL	32.6435 mL	163.2173 mL
5 mM	0.6529 mL	3.2643 mL	6.5287 mL	32.6435 mL
10 mM	0.3264 mL	1.6322 mL	3.2643 mL	16.3217 mL
20 mM	0.1632 mL	0.8161 mL	1.6322 mL	8.1609 mL
50 mM	0.0653 mL	0.3264 mL	0.6529 mL	3.2643 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6322 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc