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JYQ-164

Name: JYQ-164
Brand: TargetMol
SKU: T209973
Price: 165 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T209973

JYQ-164 is a small‑molecule inhibitor targeting human Parkinson’s disease protein 7 (PARK7/DJ‑1) with an IC₅₀ value of 21 nM. It exerts its inhibitory effect by covalently and selectively targeting the key residue Cys106 of PARK7, and its inhibitory activity against PARK7 is approximately 5‑fold higher than that of the previously reported inhibitor JYQ‑88. JYQ-164 can be used in studies related to the mechanisms of Parkinson’s disease and cancer .

JYQ-164

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Catalog No. T209973

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$165	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

Targets&IC50

PARK7:21 nM

Chemical Properties

Molecular Weight	530.62
Formula	C₂₃H₂₆N₆O₅S₂
Smiles	O=C(NC1=NC2=C(CN(C(C3=CC(S(=O)(N4CCOCC4)=O)=CC=C3)=O)CC2)S1)[C@H]5CN(C#N)CC5

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40.00 mg/mL (75.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8846 mL	9.4229 mL	18.8459 mL	94.2294 mL
5 mM	0.3769 mL	1.8846 mL	3.7692 mL	18.8459 mL
10 mM	0.1885 mL	0.9423 mL	1.8846 mL	9.4229 mL
20 mM	0.0942 mL	0.4711 mL	0.9423 mL	4.7115 mL
50 mM	0.0377 mL	0.1885 mL	0.3769 mL	1.8846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc