FOLR1 Protein, Human, Recombinant (hFc)

Name: FOLR1 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-00147
Rating: 4.5 (1 reviews)

(Synonyms: Ovarian tumor-associated antigen MOv18, FR-α, FR-alpha, FOLR1, Folate receptor α, Folate receptor alpha, Folate receptor 1, Folate receptor, FBP, Adult folate-binding protein) Copy Product Info

Synonyms: Ovarian tumor-associated antigen MOv18, FR-α, FR-alpha, FOLR1, Folate receptor α, Folate receptor alpha, Folate receptor 1, Folate receptor, FBP, Adult folate-binding protein

Catalog No. TMPJ-00147 Copy Product Info

FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.

Pack Size	Price	USA Stock	Global Stock
5 µg	$30	7-10 days	7-10 days
10 µg	$43	-	In Stock
20 µg	$68	7-10 days	7-10 days
50 µg	$133	7-10 days	7-10 days
100 µg	$252	7-10 days	7-10 days
200 µg	$487	7-10 days	7-10 days
500 µg	$1,180	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:SDS-PAGE: > 99.9%; SEC-HPLC:> 99.9%

Appearance:Solution

Color:Transparent

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Loaded Human FOLR1-Fc on APS Biosensor, can bind Anti-Human FOLR1 mAb with an affinity constant of 0.11 nM as determined in BLI assay. (Regularly tested)
Description	FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P15328
Amino Acid	Arg25-Ser234
Construction	Arg25-Ser234
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC. ,
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Ovarian tumor-associated antigen MOv18, FR-α, FR-alpha, FOLR1, Folate receptor α, Folate receptor alpha, Folate receptor 1, Folate receptor, FBP, Adult folate-binding protein
Research Background	Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Chemical Properties

Molecular Weight

55-75 kDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.