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Cifurtilimab
🥰Excellent
Catalog No. T78312Cas No. 1629760-27-5
Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, exhibiting anticancer activity for treating pancreatic cancer, advanced solid tumours, and lymphoma.
Cifurtilimab
Cifurtilimab
🥰Excellent
Purity: 95%
Catalog No. T78312Cas No. 1629760-27-5
Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, exhibiting anticancer activity for treating pancreatic cancer, advanced solid tumours, and lymphoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $859 | - | In Stock | |
| 10 mg | $1,380 | - | In Stock | |
| 25 mg | $1,980 | - | In Stock | |
| 50 mg | $2,760 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, exhibiting anticancer activity for treating pancreatic cancer, advanced solid tumours, and lymphoma. |
| In vitro | Cifurtilimab enhances FcγRIIIa binding (10-fold higher than parental IgG1 antibodies), bolstering effector functions, resulting in a stronger immunostimulatory activity compared to antibodies with silenced or selective FcγR binding [1]. Exposure to Cifurtilimab elicits distinct response features, such as the activation of APCs, CD8+ and CD4+ T cells, NK cells, and targeted depletion of CD40+ B cells [1]. |
| In vivo | In preclinical murine models, the combined use of Cifurtilimab with chemotherapy agents enhanced antitumor activity [2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Host Species | ＜ 1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID |
| Cas No. | 1629760-27-5 |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: buy Cifurtilimab | purchase Cifurtilimab | Cifurtilimab cost | order Cifurtilimab | Cifurtilimab in vivo | Cifurtilimab in vitro
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