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Cifurtilimab
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Catalog No. T78312 Copy Product Info
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Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, exhibiting anticancer activity for treating pancreatic cancer, advanced solid tumours, and lymphoma.
Cas No. 1629760-27-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $859 | - | In Stock | |
| 10 mg | $1,380 | - | In Stock | |
| 25 mg | $1,980 | - | In Stock | |
| 50 mg | $2,760 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.1% (SDS-PAGE); 98.8% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, exhibiting anticancer activity for treating pancreatic cancer, advanced solid tumours, and lymphoma. |
| In vitro | Cifurtilimab enhances FcγRIIIa binding (10-fold higher than parental IgG1 antibodies), bolstering effector functions, resulting in a stronger immunostimulatory activity compared to antibodies with silenced or selective FcγR binding [1]. Exposure to Cifurtilimab elicits distinct response features, such as the activation of APCs, CD8+ and CD4+ T cells, NK cells, and targeted depletion of CD40+ B cells [1]. |
| In vivo | In preclinical murine models, the combined use of Cifurtilimab with chemotherapy agents enhanced antitumor activity [2]. |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TNFRSF5/CD40 |
| Molecular Weight | 145.10 kDa |
| Cas No. | 1629760-27-5 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Cifurtilimab chemical structure | Cifurtilimab in vivo | Cifurtilimab in vitro | Cifurtilimab molecular weight
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