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BAY-179

Name: BAY-179
Brand: TargetMol
SKU: T9774
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9774Cas No. 2764880-87-5

BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor used for cancer research.

BAY-179

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Purity: 98.29%

Catalog No. T9774Cas No. 2764880-87-5

BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor used for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$51	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$188	In Stock	In Stock
50 mg	$291	In Stock	In Stock
100 mg	$405	In Stock	In Stock
200 mg	$538	-	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.29%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

BAY-179 AI Summary

BAY-179 is a bioactive molecule with multiple pharmacological effects across various species, including humans, mice, rats, and dogs. It primarily inhibits the electron transport chain complex 1 and shows inhibitory activity on the cardiac potassium channel ERG. The compound has good metabolic stability in rat hepatocytes and moderate oral bioavailability in Wistar rat plasma. Notably, it interacts with cytochrome P450 enzymes, particularly inhibiting CYP2C8 and CYP2C9. BAY-179 is soluble at pH 6.5 and permeable in human Caco2 cells. The compound demonstrates significant thermal shift effects, indicating potential interactions with protein domains and suggesting changes in protein structure or stability. In bioactivity assays, BAY-179 targets human lung H1299 cells. It shows high potency in a Proliferation assay with an IC50 value of 33.0 nM and in targeting the protein NDUFS2 with an IC50 value of 79.0 nM, affecting complex II substrate succinate. Additionally, BAY-179 exhibits moderate affinity for several GPCR targets, including ADRA2C, HTR2B, SIGMAR1, and TMEM97 receptors, with Ki values ranging from 558.19 to 3499.92 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor used for cancer research.

Chemical Properties

Molecular Weight	415.51
Formula	C₂₃H₂₁N₅OS
Cas No.	2764880-87-5
Smiles	C(N1CCC(C2=NC(C3=CC=4C(O3)=CC=CC4)=CS2)CC1)C=5NC=6C(N5)=NC=CC6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.55 mg/mL (100 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4067 mL	12.0334 mL	24.0668 mL	120.3340 mL
5 mM	0.4813 mL	2.4067 mL	4.8134 mL	24.0668 mL
10 mM	0.2407 mL	1.2033 mL	2.4067 mL	12.0334 mL
20 mM	0.1203 mL	0.6017 mL	1.2033 mL	6.0167 mL
50 mM	0.0481 mL	0.2407 mL	0.4813 mL	2.4067 mL
100 mM	0.0241 mL	0.1203 mL	0.2407 mL	1.2033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc