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ML 145
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Catalog No. T12074Cas No. 1164500-72-4
Alias ML145
ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
ML 145
😃Good
Purity: 97.74%
Catalog No. T12074Alias ML145Cas No. 1164500-72-4
ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $46 | In Stock | In Stock | |
| 5 mg | $107 | In Stock | In Stock | |
| 10 mg | $161 | In Stock | In Stock | |
| 25 mg | $277 | In Stock | In Stock | |
| 50 mg | $453 | In Stock | In Stock | |
| 100 mg | $636 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $117 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.74%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis. |
| Targets&IC50 | CXCR8:20.1 nM, GPR35:21.7 μM |
| In vitro | ML 145 is a selective and competitive human antagonist of GPR35/CXCR8 with an IC50/EC50 value of 20.1 nM, compared to GPR35, which is over 1000-fold more selective than GPR55, which has an IC50/EC50 value of 21.7 μM. [1] In addition, ML 145 at 10 μM completely blocked the internalization of human FLAG-GPR35-eYFP in response to various concentrations of Zaprinast, Cromolyn disodium and Pamoate. In rodents, ML 145 was ineffective in mice and showed only a slight non-competitive inhibitory effect in rats. [2] |
| Synonyms | ML145 |
| Molecular Weight | 482.57 |
| Formula | C24H22N2O5S2 |
| Cas No. | 1164500-72-4 |
| Smiles | C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CCCC(NC3=CC(O)=C(C(O)=O)C=C3)=O)C(=S)S2 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (82.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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