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ML 145

Name: ML 145
Brand: TargetMol
SKU: T12074
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12074Cas No. 1164500-72-4

Alias ML145

ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.

ML 145

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Purity: 97.74%

Catalog No. T12074Alias ML145Cas No. 1164500-72-4

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$107	In Stock
10 mg	$161	In Stock
25 mg	$277	In Stock
50 mg	$453	In Stock
100 mg	$636	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Purity:97.74%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
Targets&IC50	GPR35:21.7 μM, CXCR8:20.1 nM
In vitro	ML 145 is a selective and competitive human antagonist of GPR35/CXCR8 with an IC50/EC50 value of 20.1 nM, compared to GPR35, which is over 1000-fold more selective than GPR55, which has an IC50/EC50 value of 21.7 μM. [1] In addition, ML 145 at 10 μM completely blocked the internalization of human FLAG-GPR35-eYFP in response to various concentrations of Zaprinast, Cromolyn disodium and Pamoate. In rodents, ML 145 was ineffective in mice and showed only a slight non-competitive inhibitory effect in rats. [2]
Synonyms	ML145

Chemical Properties

Molecular Weight	482.57
Formula	C₂₄H₂₂N₂O₅S₂
Cas No.	1164500-72-4
Smiles	C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CCCC(NC3=CC(O)=C(C(O)=O)C=C3)=O)C(=S)S2
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (82.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0722 mL	10.3612 mL	20.7224 mL	103.6119 mL
5 mM	0.4144 mL	2.0722 mL	4.1445 mL	20.7224 mL
10 mM	0.2072 mL	1.0361 mL	2.0722 mL	10.3612 mL
20 mM	0.1036 mL	0.5181 mL	1.0361 mL	5.1806 mL
50 mM	0.0414 mL	0.2072 mL	0.4144 mL	2.0722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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