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11-cis Retinol

Catalog No. T38220 CAS 22737-96-8

11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle.1,211-cisRetinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells.3It promotes pigment formation in cone, but not rod, photoreceptors.

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11-cis Retinol, CAS 22737-96-8

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1 mg	35 days	$ 758.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	286.459
Formula	C20H30O
CAS No.	22737-96-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: Slightly soluble

Chloroform: Slightly soluble

References and Literature

1. Rando, R.R.The biochemistry of the visual cycleChem. Rev.101(7)1881-1896(2001) 2. Guignard, T.J.P., Jin, M., Pequignot, M.O., et al.FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin: Retinol acyltransferaseJ. Biol. Chem.285(24)18759-18768(2010) 3. Ala-Laurila, P., Cornwall, M.C., Crouch, R.K., et al.The action of 11-cis-retinol on cone opsins and intact cone photoreceptorsJ. Biol. Chem.284(24)16492-16500(2009)

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Keywords

11-cis Retinol 22737-96-8 11cis Retinol 11 cis Retinol inhibitor inhibit

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