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Anti-TrkB Antibody (1F424)

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Catalog No. TMAY-00169
Alias trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB

Anti-TrkB Antibody (1F424) is a Rabbit antibody targeting TrkB. Anti-TrkB Antibody (1F424) can be used in ELISA.

Anti-TrkB Antibody (1F424)

Anti-TrkB Antibody (1F424)

😃Good
Catalog No. TMAY-00169Alias trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Anti-TrkB Antibody (1F424) is a Rabbit antibody targeting TrkB. Anti-TrkB Antibody (1F424) can be used in ELISA.
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100 μL$269 7-10 days
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Product Introduction

Bioactivity
Description
Anti-TrkB Antibody (1F424) is a Rabbit antibody targeting TrkB. Anti-TrkB Antibody (1F424) can be used in ELISA.
Aliastrk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Ig Type
Monoclonal Rabbit IgG
Clone
1F424
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human NTRK2 / Trk-B extracellular domain (rh Trk-B; TMPY-00751; NP_001007098.1; Met 1-His 430).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins includenerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Trk-B protein (TMPY-00751)
Antigen Species
Human
Biology Area
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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