NaV1.2/1.6 channel blocker-1

Name: NaV1.2/1.6 channel blocker-1
Brand: TargetMol
SKU: T72170
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72170Cas No. 1199944-04-1

NaV1.2/1.6 channel blocker-1 is a potent inhibitor of NaV1.2 and NaV1.6 channels, exhibiting inhibitory effects on rNaV1.6 and hNaV1.2. This compound can be utilized in the study of generalized epilepsy and movement disorders.

NaV1.2/1.6 channel blocker-1

🥰Excellent

Purity: 99.54%

Catalog No. T72170Cas No. 1199944-04-1

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$78	In Stock
10 mg	$119	In Stock
25 mg	$239	In Stock
50 mg	$355	In Stock
100 mg	$527	In Stock

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	NaV1.2/1.6 channel blocker-1 is a potent inhibitor of NaV1.2 and NaV1.6 channels, exhibiting inhibitory effects on rNaV1.6 and hNaV1.2. This compound can be utilized in the study of generalized epilepsy and movement disorders.
Targets&IC50	Nav1.2 (human):24.4 μM, Nav1.6 (rat):9.8 μM
In vitro	NaV1.2/1.6 channel blocker(Compound 13)inhibits 48.5% and 34.0% of NaV1.6 and NaV1.2 sodium currents, respectively, in HEK 293 cells stably expressing rat NaV1.6 and human NaV1.2 isoforms at concentrations ranging from 1 to 100 μM [1].

Chemical Properties

Molecular Weight	258.34
Formula	C₁₄H₁₄N₂OS
Cas No.	1199944-04-1
Smiles	S=C1OC=2C=CC=CC2C3=NC(=C(N13)CCC)C

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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