PD-1 Protein, Mouse, Recombinant (His) V2

Name: PD-1 Protein, Mouse, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-00996U
Rating: 4.5 (1 reviews)

(Synonyms: programmed cell death 1, Pdc1, PD-1, Ly101) Copy Product Info

Synonyms: programmed cell death 1, Pdc1, PD-1, Ly101

Catalog No. TMPY-00996U Copy Product Info

PD-1 Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q02242.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$31	7-10 days	7-10 days
10 µg	$46	7-10 days	7-10 days
20 µg	$71	7-10 days	7-10 days
50 µg	$133	7-10 days	7-10 days
100 µg	$220	7-10 days	7-10 days
200 µg	$400	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Loaded Mouse PD-1-His on HIS1K Biosensor, can bind Biotinylated Human PD-L1-Fc-Avi with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested)
Description	PD-1 Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q02242.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	Q02242
Construction	Leu25-Gln167
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	programmed cell death 1, Pdc1, PD-1, Ly101
Research Background	Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.

Chemical Properties

Molecular Weight

17.2 kDa (Predicted); 33-40 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.