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CC-401
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Catalog No. T22639Cas No. 395104-30-0
CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).
CC-401
😃Good
Catalog No. T22639Cas No. 395104-30-0
CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $383 | 35 days | |
| 5 mg | $1,680 | 35 days | |
| 10 mg | $2,870 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CC-401 is a specific inhibitor of JNK (Ki: 25-50nM). |
| Targets&IC50 | JNK:25-50 nM (Ki) |
| In vitro | CC-401 is a second-generation ATP-competitive inhibitor of all three forms of JNK. It is selective against JNK over other kinases such as p38, ERK, IKK2, and ZAP70. CC-401 potently inhibits JNK in cell-based assay with a concentration of 1 to 5μM. The activation of JNK signaling is identified in many immune-mediated kidney disease models. Thus, as the JNK inhibitor, CC-401 is found to be effective in these renal injury models. In the acute anti-GBM disease, CC-401 inhibits JNK activation and causes a 50%-70% reduction of proteinuria. In addition, CC-401 is also used in liver injury models [1][2][3]. |
| Molecular Weight | 388.47 |
| Formula | C22H24N6O |
| Cas No. | 395104-30-0 |
| Relative Density. | 1.275 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥19.4 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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