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SRI-011381

Name: SRI-011381
Brand: TargetMol
SKU: T4283
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4283Cas No. 1629138-41-5

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

SRI-011381

🥰Excellent

Purity: 98.64%

Catalog No. T4283Cas No. 1629138-41-5

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$113	In Stock
25 mg	$239	In Stock
50 mg	$389	In Stock
100 mg	$582	In Stock
200 mg	$828	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Batch Information

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Purity:98.64%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.

Chemical Properties

Molecular Weight	329.48
Formula	C₂₀H₃₁N₃O
Cas No.	1629138-41-5
Smiles	O=C(NC1CCCCC1)N(CC1CCNCC1)Cc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (166.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0351 mL	15.1754 mL	30.3509 mL	151.7543 mL
5 mM	0.6070 mL	3.0351 mL	6.0702 mL	30.3509 mL
10 mM	0.3035 mL	1.5175 mL	3.0351 mL	15.1754 mL
20 mM	0.1518 mL	0.7588 mL	1.5175 mL	7.5877 mL
50 mM	0.0607 mL	0.3035 mL	0.6070 mL	3.0351 mL
100 mM	0.0304 mL	0.1518 mL	0.3035 mL	1.5175 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc