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MS37452

Name: MS37452
Brand: TargetMol
SKU: T21767
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21767Cas No. 423748-02-1

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

MS37452

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Purity: 99.39%

Catalog No. T21767Cas No. 423748-02-1

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$322	In Stock	In Stock
100 mg	$555	In Stock	In Stock
500 mg	$1,180	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Resource Download

COA HNMR HPLC

Product Introduction

MS37452 AI Summary

MS37452 demonstrates a high selectivity ratio for CBX8ChD, CBX6ChD, and CBX2ChD, but exhibits a lower selectivity ratio for CBX4ChD. It shows binding affinity to CBX7ChD, particularly in the presence of FITC-labeled SETDB1-K1170me3/H3K27me3/ANRIL-LoopC RNA, with a Ki value of 33100.0 nM and forms a ternary complex with CBX7ChD and FITC-labeled Loop C of ANRIL with a Kd value of 125300.0 nM. Additionally, MS37452 binds to Cbx7 with a Kd of 29000.0 nM and inhibits Cbx7 activity using a FITC-labeled SETDB1-K1170me3 peptide as a probe, with an IC50 of 67000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
Targets&IC50	CBX7:43 µM (Ki)

Chemical Properties

Molecular Weight	398.45
Formula	C₂₂H₂₆N₂O₅
Cas No.	423748-02-1
Smiles	COc1cccc(C(=O)N2CCN(CC2)C(=O)COc2cccc(C)c2)c1OC
Relative Density.	1.209 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (150.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5097 mL	12.5486 mL	25.0973 mL	125.4863 mL
5 mM	0.5019 mL	2.5097 mL	5.0195 mL	25.0973 mL
10 mM	0.2510 mL	1.2549 mL	2.5097 mL	12.5486 mL
20 mM	0.1255 mL	0.6274 mL	1.2549 mL	6.2743 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5097 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc