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MS37452

Name: MS37452
Brand: TargetMol
SKU: T21767
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21767Cas No. 423748-02-1

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

MS37452

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Purity: 99.39%

Catalog No. T21767Cas No. 423748-02-1

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$178	In Stock
50 mg	$322	In Stock
100 mg	$555	In Stock
500 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Batch Information

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Purity:99.39%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
Targets&IC50	CBX7:43 µM (Ki)

Chemical Properties

Molecular Weight	398.45
Formula	C₂₂H₂₆N₂O₅
Cas No.	423748-02-1
Smiles	COc1cccc(C(=O)N2CCN(CC2)C(=O)COc2cccc(C)c2)c1OC
Relative Density.	1.209 g/cm3 (Predicted)
Color	Transparent
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (150.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5097 mL	12.5486 mL	25.0973 mL	125.4863 mL
5 mM	0.5019 mL	2.5097 mL	5.0195 mL	25.0973 mL
10 mM	0.2510 mL	1.2549 mL	2.5097 mL	12.5486 mL
20 mM	0.1255 mL	0.6274 mL	1.2549 mL	6.2743 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5097 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc