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Anti-Osteoprotegerin Antibody (7E614)
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Catalog No. TMAY-00543
Alias tumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565
Anti-Osteoprotegerin Antibody (7E614) is a Rabbit antibody targeting Osteoprotegerin. Anti-Osteoprotegerin Antibody (7E614) can be used in ELISA.
Anti-Osteoprotegerin Antibody (7E614)
Anti-Osteoprotegerin Antibody (7E614)
😃Good
Catalog No. TMAY-00543Alias tumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565
Anti-Osteoprotegerin Antibody (7E614) is a Rabbit antibody targeting Osteoprotegerin. Anti-Osteoprotegerin Antibody (7E614) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | tumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565 |
| Ig Type | Rabbit IgG |
| Clone | 7E614 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Osteoprotegerin / TNFRSF11B (rh Osteoprotegerin / TNFRSF11B; TMPY-01724; NP_002537.3; Met 1-Leu 401). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Osteoprotegerin / TNFRSF11B protein (TMPY-01724) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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