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Fanapanel
🥰Excellent
Catalog No. T13405LCas No. 161605-73-8
Alias ZK200775, ZK 200775, MPQX
Fanapanel (ZK200775) is a quinoxalinedione derivative and potent competitive antagonist of AMPAR for cerebrovascular-related studies.
Fanapanel
🥰Excellent
Catalog No. T13405LAlias ZK200775, ZK 200775, MPQXCas No. 161605-73-8
Fanapanel (ZK200775) is a quinoxalinedione derivative and potent competitive antagonist of AMPAR for cerebrovascular-related studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $72 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Fanapanel (ZK200775) is a quinoxalinedione derivative and potent competitive antagonist of AMPAR for cerebrovascular-related studies. |
| Targets&IC50 | AMPA/kainate receptor:21 nM |
| In vitro | In rat cortical slice experiments, the inhibitory effect of Fanapanel on AMPA receptors was measured to assess its activity. The Results showed that the IC50 value for Fanapanel's inhibition of AMPA-induced currents was 21 nM, demonstrating strong neuroprotective and anticonvulsant effects [1]. |
| In vivo | In the permanent MCAO model, intravenous infusion of Fanapanel (0.1-10 mg/kg/h for 6 hours) reduced the infarct volume by 24-34%, and it remained effective even when administered 1-5 hours later (reducing infarct volume by 20-30%). In the transient MCAO model, immediate or delayed injection of Fanapanel (0.01-3 mg/kg/h) 2 hours after reperfusion reduced the infarct volume by approximately 45%. In the gerbil global cerebral ischemia model, Fanapanel protected the hippocampal CA1 region. Long-term toxicity studies (rats 6 mg/kg/h, dogs 0.2 mg/kg/h for 4 weeks) did not show renal or neurotoxicity [1]. |
| Alias | ZK200775, ZK 200775, MPQX |
| Molecular Weight | 409.25 |
| Formula | C14H15F3N3O6P |
| Cas No. | 161605-73-8 |
| Smiles | O=C1NC=2C=C(C(=CC2N(C1=O)CP(=O)(O)O)N3CCOCC3)C(F)(F)F |
| Relative Density. | 1.615g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.44 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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