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GSK205

Name: GSK205
Brand: TargetMol
SKU: T11480
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11480Cas No. 1263068-83-2

GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.

GSK205

🥰Excellent

Purity: 99.46%

Catalog No. T11480Cas No. 1263068-83-2

GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.

Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$156	In Stock
10 mg	$259	In Stock
25 mg	$573	In Stock
50 mg	$957	In Stock
100 mg	$1,480	In Stock
200 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$165	In Stock

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Batch Information

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Purity:99.46%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
Targets&IC50	TRPV4:4.19 μM
In vitro	In T3-F442A adipocytes, GSK205 (5 μM; 4 days) resulted in increased expression of thermogenic genes and was accompanied by a decrease in the proinflammatory gene program[1].
In vivo	In male C57BL/6J mice on a high-fat diet, GSK205 (10 mg/kg; intraperitoneal injection; twice daily; for 7 days) caused a reduced expression of proinflammatory chemokines, macrophage markers, and Tnfa in EPI fat. It also significantly improved glucose tolerance in diet-induced obese (DIO) mice[1].

Chemical Properties

Molecular Weight	481.45
Formula	C₂₄H₂₅BrN₄S
Cas No.	1263068-83-2
Smiles	Br.CN(CCc1ccc(Nc2ncc(s2)-c2cccnc2)cc1)Cc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (207.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0771 mL	10.3853 mL	20.7706 mL	103.8529 mL
5 mM	0.4154 mL	2.0771 mL	4.1541 mL	20.7706 mL
10 mM	0.2077 mL	1.0385 mL	2.0771 mL	10.3853 mL
20 mM	0.1039 mL	0.5193 mL	1.0385 mL	5.1926 mL
50 mM	0.0415 mL	0.2077 mL	0.4154 mL	2.0771 mL
100 mM	0.0208 mL	0.1039 mL	0.2077 mL	1.0385 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc