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GSK205

Name: GSK205
Brand: TargetMol
SKU: T11480
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11480Cas No. 1263068-83-2

GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.

GSK205

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Purity: 99.46%

Catalog No. T11480Cas No. 1263068-83-2

GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$546	In Stock	In Stock
50 mg	$892	In Stock	In Stock
100 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$165	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.46%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
Targets&IC50	TRPV4:4.19 μM
In vitro	In T3-F442A adipocytes, GSK205 (5 μM; 4 days) resulted in increased expression of thermogenic genes and was accompanied by a decrease in the proinflammatory gene program[1].
In vivo	In male C57BL/6J mice on a high-fat diet, GSK205 (10 mg/kg; intraperitoneal injection; twice daily; for 7 days) caused a reduced expression of proinflammatory chemokines, macrophage markers, and Tnfa in EPI fat. It also significantly improved glucose tolerance in diet-induced obese (DIO) mice[1].

Chemical Properties

Molecular Weight	481.45
Formula	C₂₄H₂₅BrN₄S
Cas No.	1263068-83-2
Smiles	Br.CN(CCc1ccc(Nc2ncc(s2)-c2cccnc2)cc1)Cc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (207.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0771 mL	10.3853 mL	20.7706 mL	103.8529 mL
5 mM	0.4154 mL	2.0771 mL	4.1541 mL	20.7706 mL
10 mM	0.2077 mL	1.0385 mL	2.0771 mL	10.3853 mL
20 mM	0.1039 mL	0.5193 mL	1.0385 mL	5.1926 mL
50 mM	0.0415 mL	0.2077 mL	0.4154 mL	2.0771 mL
100 mM	0.0208 mL	0.1039 mL	0.2077 mL	1.0385 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc