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K-8012

Name: K-8012
Brand: TargetMol
SKU: T24240
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24240Cas No. 1346513-17-4

Alias K8012, K 8012

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

K-8012

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Purity: 99.72%

Catalog No. T24240Alias K8012, K 8012Cas No. 1346513-17-4

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$395	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
500 mg	$2,270	-	In Stock
1 mL x 10 mM (in DMSO)	$281	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

K-8012 AI Summary

K-8012 exhibits a binding affinity to the human GST-tagged RXRalpha ligand binding domain. This was specifically evaluated through the inhibition of 9-cis-RA-induced coactivator recruitment using a TR-FRET assay, which yielded an IC50 value of 10,000 nM for the compound..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
Synonyms	K8012, K 8012

Chemical Properties

Molecular Weight	374.45
Formula	C₂₃H₂₃FN₄
Cas No.	1346513-17-4
Smiles	C(=C/1\C=2C(C(CCC=3NN=NN3)=C1C)=CC(F)=CC2)\C4=CC=C(C(C)C)C=C4
Relative Density.	1.223 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (160.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6706 mL	13.3529 mL	26.7058 mL	133.5292 mL
5 mM	0.5341 mL	2.6706 mL	5.3412 mL	26.7058 mL
10 mM	0.2671 mL	1.3353 mL	2.6706 mL	13.3529 mL
20 mM	0.1335 mL	0.6676 mL	1.3353 mL	6.6765 mL
50 mM	0.0534 mL	0.2671 mL	0.5341 mL	2.6706 mL
100 mM	0.0267 mL	0.1335 mL	0.2671 mL	1.3353 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc