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Indirubin Derivative E804

Name: Indirubin Derivative E804
Brand: TargetMol
SKU: T11654
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11654Cas No. 854171-35-0

Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.

Indirubin Derivative E804

🥰Excellent

Purity: 98.54%

Catalog No. T11654Cas No. 854171-35-0

Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$85	In Stock
10 mg	$133	In Stock
25 mg	$218	In Stock
50 mg	$325	In Stock
100 mg	$483	In Stock
200 mg	$691	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.54%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.
Targets&IC50	CDK2-CyclinE:0.23 μM (EC50), IGF-1R:0.65 μM
In vitro	Indirubin Derivative E804 is a water-soluble derivative that effectively inhibits insulin-like growth factor 1 receptor (IGF1R) with an IC50 of 0.65 μM. In addition, Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM. [1]

Chemical Properties

Molecular Weight	365.38
Formula	C₂₀H₁₉N₃O₄
Cas No.	854171-35-0
Smiles	O=C1NC=2C=CC=CC2C1=C3NC=4C=CC=CC4C3=NOCCC(O)CO
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (273.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7369 mL	13.6844 mL	27.3688 mL	136.8438 mL
5 mM	0.5474 mL	2.7369 mL	5.4738 mL	27.3688 mL
10 mM	0.2737 mL	1.3684 mL	2.7369 mL	13.6844 mL
20 mM	0.1368 mL	0.6842 mL	1.3684 mL	6.8422 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7369 mL
100 mM	0.0274 mL	0.1368 mL	0.2737 mL	1.3684 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc