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Tiratricol

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Catalog No. T1604Cas No. 51-24-1
Alias 3,3',5-Triiodothyroacetic acid

Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.

Tiratricol

Tiratricol

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Purity: 99.16%
Catalog No. T1604Alias 3,3',5-Triiodothyroacetic acidCas No. 51-24-1
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$33In StockIn Stock
100 mg$48In StockIn Stock
200 mg$60In StockIn Stock
500 mg$95In StockIn Stock
1 g$138-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.16%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
In vivo
Research indicates that Tiratricol can reduce thyroid enlargement and mitigate atrophy caused by decreased use of corticosteroid hormones. Furthermore, Tiratricol is effective in treating thyroid hormone resistance syndrome and, in combination with thyroxine, can suppress the production of thyroid-stimulating hormone in patients with thyroid cancer.
Synonyms3,3',5-Triiodothyroacetic acid
Chemical Properties
Molecular Weight621.93
FormulaC14H9I3O4
Cas No.51-24-1
SmilesO(C1=C(I)C=C(CC(O)=O)C=C1I)C2=CC(I)=C(O)C=C2
Relative Density.2.466 g/cm3
Storage & Solubility Information
StorageThe compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble), The compound is unstable in solution. Please use soon.
DMSO: 93 mg/mL (149.53 mM), Sonication is recommended. The compound is unstable in solution. Please use soon.
Ethanol: 93 mg/mL (149.53 mM), Sonication is recommended. The compound is unstable in solution. Please use soon.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.31 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.6079 mL8.0395 mL16.0790 mL80.3949 mL
5 mM0.3216 mL1.6079 mL3.2158 mL16.0790 mL
10 mM0.1608 mL0.8039 mL1.6079 mL8.0395 mL
20 mM0.0804 mL0.4020 mL0.8039 mL4.0197 mL
50 mM0.0322 mL0.1608 mL0.3216 mL1.6079 mL
100 mM0.0161 mL0.0804 mL0.1608 mL0.8039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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