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Kallikrein 5/KLK5 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01405
Synonyms: Stratum Corneum Tryptic Enzyme, Kallikrein-Like Protein 2, KLK5, Kallikrein-5, KLK-L2, SCTE

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

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Kallikrein 5/KLK5 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
50 μg 5 days $ 350.00
500 μg 5 days $ 1,220.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Biological Information Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is 622 pmol/min/µg, as measured under the described conditions. (Regularly tested)
Description Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number Q9Y337
Synonyms Stratum Corneum Tryptic Enzyme, Kallikrein-Like Protein 2, KLK5, Kallikrein-5, KLK-L2, SCTE
Amino Acid Val23-Ser293
Construction Recombinant Human Kallikrein 5 is produced by our Mammalian expression system and the target gene encoding Val23-Ser293 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.

Molecular Weight 40 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

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Keywords

Kallikrein 5/KLK5 Protein, Human, Recombinant (His) Stratum Corneum Tryptic Enzyme Kallikrein-Like Protein 2 KLK5 KLK-5 KLK 5 Kallikrein-5 KLK-L2 SCTE recombinant recombinant-proteins proteins protein

 

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