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Anti-Ano1 Antibody (1J659)
(Synonyms: TMEM16A, TAOS2, ORAOV2, MYMY7, INDMS, FLJ10261, DOG1, ANO1) Copy Product Info
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Synonyms: TMEM16A, TAOS2, ORAOV2, MYMY7, INDMS, FLJ10261, DOG1, ANO1
Catalog No. TMAY-00516 Copy Product Info
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Anti-Ano1 Antibody (1J659) is a Rabbit antibody targeting Ano1. Anti-Ano1 Antibody (1J659) can be used in WB.
Anti-Ano1 Antibody
(1J659)
(1J659)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $268 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Ano1 Antibody (1J659) is a Rabbit antibody targeting Ano1. Anti-Ano1 Antibody (1J659) can be used in WB. |
| Synonyms | TMEM16A, TAOS2, ORAOV2, MYMY7, INDMS, FLJ10261, DOG1, ANO1 |
| Ig Type | Rabbit IgG |
| Clone | 1J659 |
| Reactivity | Human |
| Specificity | Human ANO1 |
| Application | |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the C-terminus of the Human Ano1. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Anoctamin1 (Ano1 and TMEM16A) is a calcium-activated chloride channel specifically expressed in the interstitial cells of Cajal (ICC) of the gastrointestinal tract muscularis propria. Ano1 is a recently discovered Ca(2+)-activated Cl(-) channel expressed on interstitial cells of Cajal (ICC) that has been implicated in slow-wave activity in the gut. However, Ano1 is expressed on all classes of ICC, even those that do not contribute to generation of the slow wave, suggesting that Ano1 may have an alternate function in these cells. Ano1 is also highly expressed in gastrointestinal stromal tumors. Mice lacking Ano1 had fewer proliferating ICC in whole mount preparations and in culture, raising the possibility that Ano1 is involved in proliferation. Ano1 had less phosphorylated retinoblastoma protein compared with controls. Ano1 regulates proliferation at the G(1)/S transition of the cell cycle and may play a role in tumorigenesis. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: C-terminus of the Human Ano1 |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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