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740 Y-P acetate

Name: 740 Y-P acetate
Brand: TargetMol
SKU: TQ0003L1
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0003L1

Alias PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)

740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.

740 Y-P acetate

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Purity: 99.92%

Catalog No. TQ0003L1Alias PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	-	In Stock
2 mg	$139	-	In Stock
5 mg	$265	-	In Stock
10 mg	$393	-	In Stock
25 mg	$658	-	In Stock
50 mg	$937	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.
Targets&IC50	PI3K:20 μM
In vitro	740 Y-P TFA (1 μg/mL) stimulates Mitosis at the lowest concentration tested. The peptide stimulates Mitosis in the presence and absence of serum (0.5%). In the former instance, The maximum reaction was observed at 50 μg/mL. 740Y-P stimulation of Mitosis is highly specific, rather than the general characteristics of cell-permeable SH2 domain binding peptides. [1] 740 Y-P TFA (50 μg/ml; 48 h) in the culture medium, the specific stimulation of Mitosis was superior to EGF or FGF in stimulating the entry of S phase, which showed that the percentage of S phase cells in C2 cells was 48.3%. In addition, LY294002 or wortmannin effectively inhibited the Mitosis response stimulated by the 740Y-P TFA peptide. [1] 740 Y-P TFA (30 μM; 24 h) significantly inhibited the levels of LC3-II/LC3-I in GO induced PC12 cells. [2]
Synonyms	PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)

Chemical Properties

Molecular Weight	3330.79
Formula	C₁₄₃H₂₂₆N₄₃O₄₁PS₃
Smiles	O=P(O)(O)OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)NC(CNC(CNC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{Tyr(PO2)}-Met-Asp-Met-Ser
Sequence Short	RQIKIWFQNRRMKWKKSDGG-{Tyr(PO2)}-MDMS

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 83.3 mg/mL (25.01 mM), Sonication is recommended.

DMSO: 83.3 mg/mL (25.01 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.3002 mL	1.5011 mL	3.0023 mL	15.0115 mL
5 mM	0.0600 mL	0.3002 mL	0.6005 mL	3.0023 mL
10 mM	0.0300 mL	0.1501 mL	0.3002 mL	1.5011 mL
20 mM	0.0150 mL	0.0751 mL	0.1501 mL	0.7506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc