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740 Y-P acetate

Catalog No. TQ0003L1 CAS TQ0003L1

Synonyms: PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)

740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.

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740 Y-P acetate, CAS TQ0003L1

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1 mg	In stock	$ 95.00
5 mg	In stock	$ 283.00
10 mg	In stock	$ 437.00
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Biological Description

Chemical Properties

Storage & Solubility Information

Description	740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.
Targets&IC50	PI3K:20 μM
In vitro	740 Y-P TFA (1 μg/mL) stimulates Mitosis at the lowest concentration tested. The peptide stimulates Mitosis in the presence and absence of serum (0.5%). In the former instance, The maximum reaction was observed at 50 μg/mL. 740Y-P stimulation of Mitosis is highly specific, rather than the general characteristics of cell-permeable SH2 domain binding peptides. [1] 740 Y-P TFA (50 μg/ml; 48 h) in the culture medium, the specific stimulation of Mitosis was superior to EGF or FGF in stimulating the entry of S phase, which showed that the percentage of S phase cells in C2 cells was 48.3%. In addition, LY294002 or wortmannin effectively inhibited the Mitosis response stimulated by the 740Y-P TFA peptide. [1] 740 Y-P TFA (30 μM; 24 h) significantly inhibited the levels of LC3-II/LC3-I in GO induced PC12 cells. [2]

Synonyms	PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)
Molecular Weight	3330.79
Formula	C143H226N43O41PS3
CAS No.	TQ0003L1

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 83.3 mg/mL (25 mM)

DMSO: 83.3 mg/mL (25 mM)

References and Literature

1. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998;251(1):148-152. 2. Feng X, et al. Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. Acta Biomater. 2018;81:278-29

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Keywords

740 Y-P acetate TQ0003L1 PI3K/Akt/mTOR signaling PI3K PDGFR 740Y-P Acetate 740YPDGFR acetate 740YPDGFR Acetate 740 Y-P acetate(1236188-16-1 Free base) 740 Y-P Acetate inhibitor inhibit

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