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WT1 126-134 peptide

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Catalog No. TP3882Cas No. 256952-63-3

WT1 126-134 peptide is a WT1 polypeptide (Wilms' tumor 1 peptide) (RMFPNAPYL) that activates cytotoxic CD8 T cells to target and destroy WT1+ tumor cells. It can form stable complexes with either H-2Db (murine) or HLA-A0201 (human) molecules. The WT1 126-134 peptide/HLA-A0201 complex exhibits high affinity for humanized monoclonal antibodies (IgG1), with a dissociation constant (Kd) of 0.2 nM. This peptide can be utilized as a T cell vaccine or an antibody target.

WT1 126-134 peptide

WT1 126-134 peptide

😃Good
Catalog No. TP3882Cas No. 256952-63-3
WT1 126-134 peptide is a WT1 polypeptide (Wilms' tumor 1 peptide) (RMFPNAPYL) that activates cytotoxic CD8 T cells to target and destroy WT1+ tumor cells. It can form stable complexes with either H-2Db (murine) or HLA-A0201 (human) molecules. The WT1 126-134 peptide/HLA-A0201 complex exhibits high affinity for humanized monoclonal antibodies (IgG1), with a dissociation constant (Kd) of 0.2 nM. This peptide can be utilized as a T cell vaccine or an antibody target.
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Product Introduction

Bioactivity
Description
WT1 126-134 peptide is a WT1 polypeptide (Wilms' tumor 1 peptide) (RMFPNAPYL) that activates cytotoxic CD8 T cells to target and destroy WT1+ tumor cells. It can form stable complexes with either H-2Db (murine) or HLA-A0201 (human) molecules. The WT1 126-134 peptide/HLA-A0201 complex exhibits high affinity for humanized monoclonal antibodies (IgG1), with a dissociation constant (Kd) of 0.2 nM. This peptide can be utilized as a T cell vaccine or an antibody target.
In vivo
The WT1 126-134 peptide (100 μg, emulsified in incomplete Freund's adjuvant, administered via intraperitoneal injection once a week for two weeks) can induce epitope-specific CTLs but does not translate into a significant antitumor effect in the TRAMP-C2 model. However, when WT1 126-134 peptide is used in combination with the helper peptide (WT1 35-52) and administered (100 μg, emulsified in incomplete Freund's adjuvant, intraperitoneal injection once a week for three weeks), it significantly enhances CTL induction and delays tumor growth in mice induced by mWT1-C1498 cells.
Chemical Properties
Molecular Weight1108.31
FormulaC52H77N13O12S
Cas No.256952-63-3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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