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H-Ile-Pro-Pro-OH hydrochloride

Name: H-Ile-Pro-Pro-OH hydrochloride
Brand: TargetMol
SKU: T73810
Rating: 4.5 (1 reviews)

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H-Ile-Pro-Pro-OH hydrochloride, a tripeptide derived from dairy products, consists of one isoleucine (Ile) and two prolines (Pro). H-Ile-Pro-Pro-OH hydrochloride inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. H-Ile-Pro-Pro-OH hydrochloride exhibits antihypertensive effects.

Cas No. 1208862-61-6

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	H-Ile-Pro-Pro-OH hydrochloride, a tripeptide derived from dairy products, consists of one isoleucine (Ile) and two prolines (Pro). H-Ile-Pro-Pro-OH hydrochloride inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. H-Ile-Pro-Pro-OH hydrochloride exhibits antihypertensive effects.
Targets & IC50	ACE:5 μM
In vitro	H-Ile-Pro-Pro-OH hydrochloride (1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in HUVECs. [1]
In vivo	Methods: To investigate the effects of H-Ile-Pro-Pro-OH hydrochloride on acetylcholine-induced vasodilation, L-NAME was administered (1 g/L in drinking water) In an in vitro organ bath using thoracic aortic rings from Wistar rats, ACh (1–10 μmol/L) was added cumulatively following pre-constriction with phenylephrine, followed by administration of H-Ile-Pro-Pro-OH hydrochloride via drinking water (0.3 g/L, approximately 30 mg/kg/day) for 4 weeks. Results: H-Ile-Pro-Pro-OH hydrochloride significantly attenuated acetylcholine-induced vasodilation. [1]

Chemical Properties

Molecular Weight	361.86
Formula	C₁₆H₂₈ClN₃O₄
Cas No.	1208862-61-6
Smiles	C(=O)([C@H]1N(C([C@H]([C@H](CC)C)N)=O)CCC1)N2[C@H](C(O)=O)CCC2.Cl
Sequence	H-Ile-Pro-Pro-OH.HCl
Sequence Short	IPP

Storage & Solubility Information

Storage

Keep away from moistureKeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 29.34 mg/mL (81.08 mM), Sonication is recommended.

H2O: 44 mg/mL (121.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.7635 mL	13.8175 mL	27.6350 mL	138.1750 mL
5 mM	0.5527 mL	2.7635 mL	5.5270 mL	27.6350 mL
10 mM	0.2763 mL	1.3817 mL	2.7635 mL	13.8175 mL
20 mM	0.1382 mL	0.6909 mL	1.3817 mL	6.9087 mL
50 mM	0.0553 mL	0.2763 mL	0.5527 mL	2.7635 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0276 mL	0.1382 mL	0.2763 mL	1.3817 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: H-Ile-Pro-Pro-OH hydrochloride chemical structure | H-Ile-Pro-Pro-OH hydrochloride in vivo | H-Ile-Pro-Pro-OH hydrochloride in vitro | H-Ile-Pro-Pro-OH hydrochloride formula | H-Ile-Pro-Pro-OH hydrochloride molecular weight