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RIPK1-IN-19
🥰Excellent
Catalog No. T87334Cas No. 2763831-43-0
RIPK1-IN-19 is a selective and potent bimodal RIPK1 inhibitor with IC50=15 nM that protects against cell necrosis and works well in the tnf α-induced Systemic Inflammatory Response Syndrome (SIRS) model and imiquimod (IMQ)-induced psoriasis model.
RIPK1-IN-19
🥰Excellent
Purity: 98.81%
Catalog No. T87334Cas No. 2763831-43-0
RIPK1-IN-19 is a selective and potent bimodal RIPK1 inhibitor with IC50=15 nM that protects against cell necrosis and works well in the tnf α-induced Systemic Inflammatory Response Syndrome (SIRS) model and imiquimod (IMQ)-induced psoriasis model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $277 | In Stock | |
| 25 mg | $556 | In Stock | |
| 50 mg | $887 | In Stock | |
| 100 mg | $1,390 | In Stock | |
| 200 mg | $1,890 | In Stock |
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CitedICCB-19 hydrochloride Cited
ICCB-19 HCl(750621-52-4 free base)
T8931L1803605-68-6
ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
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CitedSelect Batch
Purity:98.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RIPK1-IN-19 is a selective and potent bimodal RIPK1 inhibitor with IC50=15 nM that protects against cell necrosis and works well in the tnf α-induced Systemic Inflammatory Response Syndrome (SIRS) model and imiquimod (IMQ)-induced psoriasis model. |
| Targets&IC50 | RIPK1:15 nM |
| Molecular Weight | 496.54 |
| Formula | C28H25FN6O2 |
| Cas No. | 2763831-43-0 |
| Smiles | C(N[C@@H](C)C1=CC(F)=CC=C1)(=O)C=2C=3C(N(C)C2)=CC=C(C3)C4=CC=5N(C=C4)N=C(NC(=O)C6CC6)N5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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