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PAF (C16)

Catalog No. T21547 CAS 74389-68-7

Synonyms: C16-PAF

PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.

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PAF (C16), CAS 74389-68-7

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50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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Biological Description

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Description

In vitro

In PAFR+/+ cultures, C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) does not elicit significant concentration-dependent neuronal loss, whereas it does induce significant concentration-dependent neuronal loss in PAFR?/? cultures. Specifically, C16-PAF (1 μM) induces neuronal death in PAFR?/? cells infected with EGFP alone[1].In PAFR neurons, C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3[1].
Synthesized by two distinct pathways, the remodeling pathway and the de novo synthesis pathway, C16-PAF acts by binding to a unique G-protein-coupled seven-transmembrane receptor[2][3].
Furthermore, C16-PAF (1-25 μg/ml; 6, 12, 24 h) exhibits time-dependent inhibition of M. smegmatis and M. bovis BCG growth[3].

Synonyms	C16-PAF
Molecular Weight	523.68
Formula	C26H54NO7P
CAS No.	74389-68-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (57.29 mM), Sonication is recommended.

DMSO: 40 mg/mL (76.38 mM), Sonication is recommended.

References and Literature

1. Scott D Ryan, et al. Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. J Lipid Res. 2008 Oct;49(10):2250-8. 2. Z Honda, et al. Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J Biol Chem. 1994 Jan 21;269(3):2307-15. 3. Muhammad S Riaz, et al. Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. Front Microbiol. 2018 Sep 11;9:1903.

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Keywords

PAF (C16) 74389-68-7 MAPK Metabolism ERK MEK Endogenous Metabolite C16-PAF C16 PAF C-16 C 16 inhibitor inhibit

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