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Anti-CGAS Polyclonal Antibody

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Catalog No. TMAB-00419
Alias MB21D1, Mab-21 domain-containing protein 1, h-cGAS, Cyclic GMP-AMP synthase, cGAS, cGAMP synthase, C6orf150, 2'3'-cGAMP synthase

Anti-CGAS Polyclonal Antibody is a Rabbit antibody targeting CGAS. Anti-CGAS Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.

Anti-CGAS Polyclonal Antibody

Anti-CGAS Polyclonal Antibody

😃Good
Catalog No. TMAB-00419Alias MB21D1, Mab-21 domain-containing protein 1, h-cGAS, Cyclic GMP-AMP synthase, cGAS, cGAMP synthase, C6orf150, 2'3'-cGAMP synthase
Anti-CGAS Polyclonal Antibody is a Rabbit antibody targeting CGAS. Anti-CGAS Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3737-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-CGAS Polyclonal Antibody is a Rabbit antibody targeting CGAS. Anti-CGAS Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P.
SynonymsMB21D1, Mab-21 domain-containing protein 1, h-cGAS, Cyclic GMP-AMP synthase, cGAS, cGAMP synthase, C6orf150, 2'3'-cGAMP synthase
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Verified Activity
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-C6orf150 Polyclonal Antibody, Unconjugated (TMAB-00419) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500; ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm, cytosol.
Tissue SpecificityExpressed in the monocytic cell line THP1.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundMaking up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf150 gene product has been provisionally designated C6orf150 pending further characterization.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human C6orf150
Antigen Species
Human
Gene Name
CGAS
Gene ID
Protein Name
Cyclic GMP-AMP synthase
Uniprot ID
Biology Area
Other Antibodies
Function
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[G(2,5)pA(3,5)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
(Microbial infection) Upon M.tuberculosis infection THP-1 cells knocked-out for this gene have impaired type-I interferon production (IF-1 beta), nor do they produce type-I IFN upon transfection with dsDNA (PubMed:26048138).
Chemical Properties
Molecular WeightTheoretical: 59 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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