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Edonentan

Name: Edonentan
Brand: TargetMol
SKU: T31605
Price: 593 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31605Cas No. 210891-04-6

Alias BMS-207940, BMS207940, BMS 207940

Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.

Edonentan

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Purity: 99.13%

Catalog No. T31605Alias BMS-207940, BMS207940, BMS 207940Cas No. 210891-04-6

Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$593	In Stock	In Stock
5 mg	$1,180	In Stock	In Stock
10 mg	$1,320	In Stock	In Stock
25 mg	$1,510	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.13%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Edonentan AI Summary

Edonentan inhibits the endothelin receptor type A with a Ki of 10.0 nM, but does not exhibit significant activity against the angiotensin II receptor type 1, as its Ki value exceeds 10.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
Targets&IC50	ETB:810 nM (Ki), ETA:10 pM (Ki)
Synonyms	BMS-207940, BMS207940, BMS 207940

Chemical Properties

Molecular Weight	536.64
Formula	C₂₈H₃₂N₄O₅S
Cas No.	210891-04-6
Smiles	C(N(C(CC(C)(C)C)=O)C)C1=C(C=CC(=C1)C2=NC=CO2)C3=C(S(NC=4C(C)=C(C)ON4)(=O)=O)C=CC=C3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8634 mL	9.3172 mL	18.6345 mL	93.1723 mL
5 mM	0.3727 mL	1.8634 mL	3.7269 mL	18.6345 mL
10 mM	0.1863 mL	0.9317 mL	1.8634 mL	9.3172 mL
20 mM	0.0932 mL	0.4659 mL	0.9317 mL	4.6586 mL
50 mM	0.0373 mL	0.1863 mL	0.3727 mL	1.8634 mL
100 mM	0.0186 mL	0.0932 mL	0.1863 mL	0.9317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc