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Edonentan

Name: Edonentan
Brand: TargetMol
SKU: T31605
Price: 593 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T31605Cas No. 210891-04-6

Alias BMS-207940, BMS207940, BMS 207940

Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.

Edonentan

🥰Excellent

Purity: 99.6%

Catalog No. T31605Alias BMS-207940, BMS207940, BMS 207940Cas No. 210891-04-6

Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.

Pack Size	Price	Availability
1 mg	$593	In Stock
5 mg	$1,180	In Stock
10 mg	$1,320	In Stock
25 mg	$1,510	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.6%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
Targets&IC50	ETB:810 nM (Ki), ET A:10 pM (Ki)
Synonyms	BMS-207940, BMS207940, BMS 207940

Chemical Properties

Molecular Weight	536.64
Formula	C₂₈H₃₂N₄O₅S
Cas No.	210891-04-6
Smiles	C(N(C(CC(C)(C)C)=O)C)C1=C(C=CC(=C1)C2=NC=CO2)C3=C(S(NC=4C(C)=C(C)ON4)(=O)=O)C=CC=C3
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8634 mL	9.3172 mL	18.6345 mL	93.1723 mL
5 mM	0.3727 mL	1.8634 mL	3.7269 mL	18.6345 mL
10 mM	0.1863 mL	0.9317 mL	1.8634 mL	9.3172 mL
20 mM	0.0932 mL	0.4659 mL	0.9317 mL	4.6586 mL
50 mM	0.0373 mL	0.1863 mL	0.3727 mL	1.8634 mL
100 mM	0.0186 mL	0.0932 mL	0.1863 mL	0.9317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc