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LDN-193189 Tetrahydrochloride

🥰Excellent
Catalog No. T63897Cas No. 2310134-98-4
Alias LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride

LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia.

LDN-193189 Tetrahydrochloride

LDN-193189 Tetrahydrochloride

🥰Excellent
Purity: 98.21%
Catalog No. T63897Alias LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 TetrahydrochlorideCas No. 2310134-98-4
LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia.
Pack SizePriceAvailabilityQuantity
1 mg$63In Stock
5 mg$143In Stock
10 mg$212In Stock
25 mg$357In Stock
50 mg$531In Stock
100 mg$758In Stock
200 mg$1,020In Stock
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Purity:98.21%
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Product Introduction

Bioactivity
Description
LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia.
Targets&IC50
ACVR1:5 nM, BMPR1A:7 nM
In vitro
LDN-193189 Tetrahydrochloride potently inhibits the kinase activity of ALK4 and ActRIIA with IC50 values of 101 and 210 nM, respectively.[2]
In vivo
Methods: SCID mice bearing MDA-PCa-118b tumor xenografts were treated with LDN-193189 Tetrahydrochloride (3 mg/kg, intraperitoneal injection, twice daily). Tumor size and body weight were measured weekly to investigate the effect of LDN-193189 Tetrahydrochloride on tumor growth in vivo. Results: Treatment of MDA-PCa-118b tumor-bearing mice with LDN-193189 Tetrahydrochloride resulted in decreased bone formation and attenuated tumor growth. [1]
SynonymsLDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride
Chemical Properties
Molecular Weight552.33
FormulaC25H26Cl4N6
Cas No.2310134-98-4
SmilesC1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl.Cl.Cl
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.3 mg/mL (5.97 mM), Sonication is recommended.
H2O: 25 mg/mL (45.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.8105 mL9.0526 mL18.1051 mL90.5256 mL
5 mM0.3621 mL1.8105 mL3.6210 mL18.1051 mL
H2O
1mg5mg10mg50mg
10 mM0.1811 mL0.9053 mL1.8105 mL9.0526 mL
20 mM0.0905 mL0.4526 mL0.9053 mL4.5263 mL

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