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LDN-193189 Tetrahydrochloride

Name: LDN-193189 Tetrahydrochloride
Brand: TargetMol
SKU: T63897
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63897Cas No. 2310134-98-4

Alias LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride

LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia.

LDN-193189 Tetrahydrochloride

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Purity: 98.21%

Catalog No. T63897Alias LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 TetrahydrochlorideCas No. 2310134-98-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$153	In Stock	In Stock
50 mg	$237	In Stock	In Stock
100 mg	$352	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.21%

Appearance:Solid

Color:Orange

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC₅₀ = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia.
Targets&IC50	ACVR1:5 nM, BMPR1A:7 nM
In vitro	LDN-193189 Tetrahydrochloride potently inhibits the kinase activity of ALK4 and ActRIIA with IC50 values of 101 and 210 nM, respectively.[2]
In vivo	Methods: SCID mice bearing MDA-PCa-118b tumor xenografts were treated with LDN-193189 Tetrahydrochloride (3 mg/kg, intraperitoneal injection, twice daily). Tumor size and body weight were measured weekly to investigate the effect of LDN-193189 Tetrahydrochloride on tumor growth in vivo. Results: Treatment of MDA-PCa-118b tumor-bearing mice with LDN-193189 Tetrahydrochloride resulted in decreased bone formation and attenuated tumor growth. [1]
Synonyms	LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride

Chemical Properties

Molecular Weight	552.33
Formula	C₂₅H₂₆Cl₄N₆
Cas No.	2310134-98-4
Smiles	C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl.Cl.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (45.26 mM), Sonication is recommended.

DMSO: 3.3 mg/mL (5.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8105 mL	9.0526 mL	18.1051 mL	90.5256 mL
5 mM	0.3621 mL	1.8105 mL	3.6210 mL	18.1051 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.1811 mL	0.9053 mL	1.8105 mL	9.0526 mL
20 mM	0.0905 mL	0.4526 mL	0.9053 mL	4.5263 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc