ALK-4/ACVR1B Protein, Human, Recombinant (GST)

Name: ALK-4/ACVR1B Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00018
Rating: 4.5 (1 reviews)

(Synonyms: SKR2, ALK-4, ALK4, ACVRLK4, ACVR1B, ACTR-IB, Activin receptor type-1B) Copy Product Info

Synonyms: SKR2, ALK-4, ALK4, ACVRLK4, ACVR1B, ACTR-IB, Activin receptor type-1B

Catalog No. TMPC-00018 Copy Product Info

ALK-4/ACVR1B Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P36896.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 µg	$1,390	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Representative specific activity data for ALK4 were obtained using different assay formats: - 18 nmol/min/mg, determined by radioactive kinase assay - 6.8 nmol/min/mg, determined by ADP-Glo kinase assay Different lots may be tested using different assay methods; therefore, values obtained using different assay formats are not directly comparable.
Description	ALK-4/ACVR1B Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P36896.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	P36896
Construction	Recombinant human ALK4 (150-end) was expressed in Sf9 cells using an N-terminal GST tag.
Protein Purity	>90% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Synonyms	SKR2, ALK-4, ALK4, ACVRLK4, ACVR1B, ACTR-IB, Activin receptor type-1B
Research Background	ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

Chemical Properties

Molecular Weight

~64 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.