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AX20017

Name: AX20017
Brand: TargetMol
SKU: T7312
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7312Cas No. 329221-38-7

AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.

AX20017

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Purity: 99.31%

Catalog No. T7312Cas No. 329221-38-7

AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$119	In Stock	In Stock
50 mg	$206	In Stock	In Stock
100 mg	$310	In Stock	In Stock
200 mg	$449	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.31%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.
Targets&IC50	PKNG:0.39 μM
In vitro	The inhibitory activity of AX20017 against the 11 known mycobacterial kinases revealed that the compound is highly selective for PknG . To test the activity of the inhibitor toward eukaryotic kinases, a screen of 28 different archetypical human kinases originating from six major protein kinase groups was set up. AX20017 did not affect the human kinases, whereas the activity of PknG was effectively inhibited[1].

Chemical Properties

Molecular Weight	264.34
Formula	C₁₃H₁₆N₂O₂S
Cas No.	329221-38-7
Smiles	NC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (121.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (12.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7830 mL	18.9150 mL	37.8301 mL	189.1503 mL
5 mM	0.7566 mL	3.7830 mL	7.5660 mL	37.8301 mL
10 mM	0.3783 mL	1.8915 mL	3.7830 mL	18.9150 mL
20 mM	0.1892 mL	0.9458 mL	1.8915 mL	9.4575 mL
50 mM	0.0757 mL	0.3783 mL	0.7566 mL	3.7830 mL
100 mM	0.0378 mL	0.1892 mL	0.3783 mL	1.8915 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc