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Anti-USP3 Polyclonal Antibody
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Catalog No. TMAB-14024
Anti-USP3 Polyclonal Antibody is a Rabbit antibody targeting USP3. Anti-USP3 Polyclonal Antibody can be used in WB.
Anti-USP3 Polyclonal Antibody
Anti-USP3 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-14024
Anti-USP3 Polyclonal Antibody is a Rabbit antibody targeting USP3. Anti-USP3 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-USP3 Polyclonal Antibody is a Rabbit antibody targeting USP3. Anti-USP3 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Sample: A549 (Human) Cell Lysate at 30 μg U2Os (Human) Cell Lysate at 30 μg Primary: Anti-USP3 (TMAB-14024) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD 2. Sample: k562 (human) Cell Lysate at 30 μg Primary: Anti-USP3 (TMAB-14024) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin. |
| Tissue Specificity | Expressed in all tissues examined, with strongest expression in pancreas. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP3 (ubiquitin specific peptidase 3), also known as UBP or SIH003, is a 520 amino acid protein that contains one UBP-type zinc finger and belongs to the peptidase C19 family. Expressed ubiquitously with highest levels present in pancreas, USP3 catalyzes the conversion of a ubiquitin C-terminal thioester to a free ubiquitin and a thiol. The gene encoding USP3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. |
| Immunogen | KLH conjugated synthetic peptide: human USP3 |
| Antigen Species | Human |
| Gene Name | USP3 |
| Gene ID | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 3 |
| Uniprot ID | |
| Function | Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. |
| Molecular Weight | Theoretical: 59 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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