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Anti-Phospho-PKR (Thr446) Antibody (6I657)
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Catalog No. TMAB-11163
Anti-Phospho-PKR (Thr446) Antibody (6I657) is a Rabbit antibody targeting Phospho-PKR (Thr446). Anti-Phospho-PKR (Thr446) Antibody (6I657) can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Phospho-PKR (Thr446) Antibody (6I657)
Anti-Phospho-PKR (Thr446) Antibody (6I657)
😃Good
Catalog No. TMAB-11163
Anti-Phospho-PKR (Thr446) Antibody (6I657) is a Rabbit antibody targeting Phospho-PKR (Thr446). Anti-Phospho-PKR (Thr446) Antibody (6I657) can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PKR (Thr446) Antibody (6I657) is a Rabbit antibody targeting Phospho-PKR (Thr446). Anti-Phospho-PKR (Thr446) Antibody (6I657) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 6I657 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | PKR is an interferon-inducible serine/threonine specific protein kinase. It is widely expressed in eukaryotic organisms and activated by double stranded RNA. Activation of PKR by dsRNAs leads to autophosphorylation at multiple sites. Phosphorylation of Thr446 and Thr451 in the PKR activation loop is required in vivo and in vitro for high level kinase activity. PKR phosphorylates its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor 2 (EIF2 alpha), leading to the inhibition of protein synthesis. PKR is also involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, and also activates IKK and NFKB, thereby suppressing apoptosis. Recently, it has been reported that PKR also phosphorylates human p53 on serine 392. PKR might play a role in ER stress-induced apoptosis and in Alzheimer's disease. Alzheimer cases show prominent PKR activation in association with neuritic plaques and pyramidal neurons in the hippocampus and neocortex. |
| Immunogen | A synthesized peptide: human eIF2A K2 around the phosphorylation site of T446 |
| Antigen Species | Human |
| Gene Name | EIF2AK2 |
| Gene ID | |
| Protein Name | Interferon-induced, double-stranded RNA-activated protein kinase |
| Uniprot ID | |
| Function | Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. |
| Molecular Weight | Theoretical: 62 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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