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AT791
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Catalog No. T61882Cas No. 1219962-49-8
Alias AT 791
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
AT791
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Purity: 99.88%
Catalog No. T61882Alias AT 791Cas No. 1219962-49-8
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $66 | In Stock | In Stock | |
| 5 mg | $158 | In Stock | In Stock | |
| 10 mg | $248 | In Stock | In Stock | |
| 25 mg | $397 | In Stock | In Stock | |
| 50 mg | $569 | In Stock | In Stock | |
| 100 mg | $786 | - | In Stock | |
| 200 mg | $1,090 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $176 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.88%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research. |
| Targets&IC50 | TLR9:0.04μM, TLR7:3.33μM |
| In vitro | AT791 effectively inhibited DNA stimulation of HEK:TLR9 cells with an IC50 value of 40 nM, respectively, but was significantly less effective in inhibiting LPS endotoxin stimulation of HEK:TLR4 cells or R848 HEK:TLR7 cells. Methods: To confirm whether the interaction of AT791 with DNA was associated with its ability to inhibit DNA-TLR9 interaction in cells, a live cell version of the oligonucleotide bait assay was developed. A non-stimulatory version of the oligonucleotide CpG2216 was created by inverting the stimulatory CpG motif to GpC to generate GpC2216. Results: Stimulatory CpG2216 induced IL-6 production in BMDCs, whereas AT791 (10 mM) inhibited this production. However, when an excess of non-stimulatory GpC2216 was added, IL-6 induction was restored. GpC2216 itself, either alone or in the presence of AT791, does not stimulate IL-6 production.[1] |
| In vivo | Short-term induction of serum interleukin-6 by CpG1668 DNA in mice could be effectively inhibited by pretreatment with AT791 (20 mg/kg).[1] |
| Synonyms | AT 791 |
| Molecular Weight | 397.51 |
| Formula | C23H31N3O3 |
| Cas No. | 1219962-49-8 |
| Smiles | N1=C(OC=2C=C(OCCCN(C)C)C=CC12)C3=CC=C(OCCCN(C)C)C=C3 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (201.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.3 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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