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Simmitecan hydrochloride

Name: Simmitecan hydrochloride
Brand: TargetMol
SKU: T71137
Price: 588 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T71137Cas No. 1247847-78-4

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Simmitecan hydrochloride

🥰Excellent

Purity: 98.93%

Catalog No. T71137Cas No. 1247847-78-4

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$588	In Stock	In Stock
5 mg	$1,280	In Stock	In Stock
25 mg	$2,570	In Stock	In Stock
50 mg	$3,380	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.93%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Chemical Properties

Molecular Weight	635.15
Formula	C₃₄H₃₉ClN₄O₆
Cas No.	1247847-78-4
Smiles	O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(OC(=O)N5CCC(CC5)N6CCCCC6)C4CC=C)=CC7=C1COC(=O)[C@@]7(CC)O.Cl
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (39.36 mM), Sonication is recommended.

DMSO: 100 mg/mL (157.44 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5744 mL	7.8722 mL	15.7443 mL	78.7216 mL
5 mM	0.3149 mL	1.5744 mL	3.1489 mL	15.7443 mL
10 mM	0.1574 mL	0.7872 mL	1.5744 mL	7.8722 mL
20 mM	0.0787 mL	0.3936 mL	0.7872 mL	3.9361 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0315 mL	0.1574 mL	0.3149 mL	1.5744 mL
100 mM	0.0157 mL	0.0787 mL	0.1574 mL	0.7872 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc