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Simmitecan hydrochloride

Name: Simmitecan hydrochloride
Brand: TargetMol
SKU: T71137
Price: 588 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71137Cas No. 1247847-78-4

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Simmitecan hydrochloride

🥰Excellent

Purity: 98.93%

Catalog No. T71137Cas No. 1247847-78-4

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$588	In Stock	In Stock
5 mg	$1,280	In Stock	In Stock
25 mg	$2,570	In Stock	In Stock
50 mg	$3,380	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.93%

ee:100%

Appearance:Solid

Color:Yellow

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Chemical Properties

Molecular Weight	635.15
Formula	C₃₄H₃₉ClN₄O₆
Cas No.	1247847-78-4
Smiles	O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(OC(=O)N5CCC(CC5)N6CCCCC6)C4CC=C)=CC7=C1COC(=O)[C@@]7(CC)O.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25 mg/mL (39.36 mM), Sonication is recommended.

DMSO: 100 mg/mL (157.44 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5744 mL	7.8722 mL	15.7443 mL	78.7216 mL
5 mM	0.3149 mL	1.5744 mL	3.1489 mL	15.7443 mL
10 mM	0.1574 mL	0.7872 mL	1.5744 mL	7.8722 mL
20 mM	0.0787 mL	0.3936 mL	0.7872 mL	3.9361 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0315 mL	0.1574 mL	0.3149 mL	1.5744 mL
100 mM	0.0157 mL	0.0787 mL	0.1574 mL	0.7872 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc