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Simmitecan hydrochloride

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TargetMol
Catalog No. T71137Cas No. 1247847-78-4

Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.

Simmitecan hydrochloride

Simmitecan hydrochloride

🥰Excellent
TargetMol
Purity: 98.93%
Catalog No. T71137Cas No. 1247847-78-4
Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.
Pack SizePriceAvailabilityQuantity
1 mg$588In Stock
5 mg$1,280In Stock
25 mg$2,570In Stock
50 mg$3,380In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.93%
ee:100%
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Product Introduction

Bioactivity
Description
Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.
Chemical Properties
Molecular Weight635.15
FormulaC34H39ClN4O6
Cas No.1247847-78-4
SmilesO=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(OC(=O)N5CCC(CC5)N6CCCCC6)C4CC=C)=CC7=C1COC(=O)[C@@]7(CC)O.Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 25 mg/mL (39.36 mM), Sonication is recommended.
DMSO: 100 mg/mL (157.44 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5744 mL7.8722 mL15.7443 mL78.7216 mL
5 mM0.3149 mL1.5744 mL3.1489 mL15.7443 mL
10 mM0.1574 mL0.7872 mL1.5744 mL7.8722 mL
20 mM0.0787 mL0.3936 mL0.7872 mL3.9361 mL
DMSO
1mg5mg10mg50mg
50 mM0.0315 mL0.1574 mL0.3149 mL1.5744 mL
100 mM0.0157 mL0.0787 mL0.1574 mL0.7872 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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